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satraplatin

Known as: (OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)platinum, bis-acetatoamminedichlorocyclohexylamine platinum(IV), platinum,bis(acetato-O)amminedichloro(cyclohexanamine)-,(OC-6-43) 
An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged… Expand
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic AgentsOrganoplatinum Compounds

Narrower (2)

BMS-182751JM 216

Papers overview

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Highly Cited
2013
Highly Cited
2013
In vivo multimodality imaging and cancer therapy by near-infrared light-triggered trans-platinum pro-drug-conjugated upconverison nanoparticles.
Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV… Expand
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Highly Cited
2010
Highly Cited
2010
The status of platinum anticancer drugs in the clinic and in clinical trials.
Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian… Expand
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Highly Cited
2009
Highly Cited
2009
Multinational, double-blind, phase III study of prednisone and either satraplatin or placebo in patients with castrate-refractory prostate cancer progressing after prior chemotherapy: the SPARC trial…
PURPOSE This multinational, double-blind, randomized, placebo-controlled, phase III trial assessed the efficacy and tolerability… Expand
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Highly Cited
2008
Highly Cited
2008
Conjugated platinum(IV)-peptide complexes for targeting angiogenic tumor vasculature.
The integrins alpha vbeta3 and alpha vbeta5 and the membrane-spanning surface protein aminopeptidase N (APN) are highly expressed… Expand
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Review
2007
Review
2007
The resurgence of platinum-based cancer chemotherapy
The accidental discovery of the anticancer properties of cisplatin and its clinical introduction in the 1970s represent a major… Expand
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Review
2007
Review
2007
Broadening the clinical use of platinum drug-based chemotherapy with new analogues. Satraplatin and picoplatin.
The three platinum-containing drugs that have been thus far approved by the FDA - cisplatin, carboplatin and oxaliplatin - have… Expand
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Highly Cited
2005
Highly Cited
2005
Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities
DNA damage often activates the p53–p21 pathway and causes G1-phase arrest in mammalian cells. Although there is ample evidence… Expand
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Highly Cited
2005
Highly Cited
2005
Phase III Trial of Satraplatin, an Oral Platinum plus Prednisone vs. Prednisone alone in Patients with Hormone-Refractory Prostate Cancer
Satraplatin is a novel oral platinum (IV) complex that shows activity against hormone-refractory prostate cancer (HRPC) in… Expand
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Highly Cited
1997
Highly Cited
1997
Activation of C−H Bonds by Metal Complexes
ion. The oxidative addition mechanism was originally proposed22i because of the lack of a strong rate dependence on polar factors… Expand
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1992
1992
Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates.
Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a… Expand
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