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satraplatin

Known as: (OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)platinum, bis-acetatoamminedichlorocyclohexylamine platinum(IV), platinum,bis(acetato-O)amminedichloro(cyclohexanamine)-,(OC-6-43) 
An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

Antineoplastic AgentsOrganoplatinum Compounds

Narrower (2)

BMS-182751JM 216
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Synthesis, X-ray crystallographic, and NMR characterizations of platinum(II) and platinum(IV) pyrophosphato complexes.
A series of mononuclear cis-diamineplatinum(II) pyrophosphato complexes containing ammine (am), trans-1,2-cyclohexanediamine… 
Highly Cited
2007
Highly Cited
2007
Preclinical antitumor activity of the oral platinum analog satraplatin
PurposeSatraplatin is an orally available platinum analog. The purpose of this study was to better characterize satraplatin’s… 
Review
2007
Review
2007
Taxane refractory prostate cancer.
2005
2005
Satraplatin in the treatment of hormone‐refractory prostate cancer
orally bioavailable. Like other platinum analogues, satraplatin appears to act by binding to DNA and forming intraand interstrand… 
2002
2002
Direct addition of alcohols to organonitriles activated by ligation to a platinum(IV) center.
Treatment of trans-[PtCl(4)(RCN)(2)] (R = Me, Et) with R'OH (R' = Me, Et, n-Pr, i-Pr, n-Bu) at 45 degrees C in all cases allowed… 
2001
2001
Five-coordinate trispyrazolylborate dihydridosilyl platinum(IV) complexes.
Highly Cited
2000
Highly Cited
2000
Iminoacylation. 3. Formation of platinum(IV)-based metallaligands due to facile one-end addition of vic-dioximes to coordinated organonitriles.
The reaction of vic-dioximes with the organonitrile platinum(IV) complexes trans-[PtCl4(RCN)2] (R = Me, CH2Ph, Ph, vic-dioxime… 
Review
1999
Review
1999
Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance.
1995
1995
Metabolic studies of an orally active platinum anticancer drug by liquid chromatography-electrospray ionization mass spectrometry.
1994
1994
Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat.
This study compared the effect on sensory nerve conduction velocity in the hind limb of chronically treated age-matched rats of a… 
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