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satraplatin

Known as: (OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)platinum, bis-acetatoamminedichlorocyclohexylamine platinum(IV), platinum,bis(acetato-O)amminedichloro(cyclohexanamine)-,(OC-6-43) 
An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV… Expand
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Highly Cited
2010
Highly Cited
2010
Since its approval in 1979 cisplatin has become an important component in chemotherapy regimes for the treatment of ovarian… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE This multinational, double-blind, randomized, placebo-controlled, phase III trial assessed the efficacy and tolerability… Expand
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Highly Cited
2008
Highly Cited
2008
The integrins alpha vbeta3 and alpha vbeta5 and the membrane-spanning surface protein aminopeptidase N (APN) are highly expressed… Expand
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Review
2007
Review
2007
The accidental discovery of the anticancer properties of cisplatin and its clinical introduction in the 1970s represent a major… Expand
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Review
2007
Review
2007
The three platinum-containing drugs that have been thus far approved by the FDA - cisplatin, carboplatin and oxaliplatin - have… Expand
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Highly Cited
2005
Highly Cited
2005
DNA damage often activates the p53–p21 pathway and causes G1-phase arrest in mammalian cells. Although there is ample evidence… Expand
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Highly Cited
2005
Highly Cited
2005
Satraplatin is a novel oral platinum (IV) complex that shows activity against hormone-refractory prostate cancer (HRPC) in… Expand
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Highly Cited
1997
Highly Cited
1997
ion. The oxidative addition mechanism was originally proposed22i because of the lack of a strong rate dependence on polar factors… Expand
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1992
1992
Acquired resistance to cisplatin has been generated in vitro in two human ovarian carcinoma cell lines: 41M, established from a… Expand
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