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saposin

National Institutes of Health

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Saposins

Papers overview

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2015
2015
BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts.
Saposin (Sap) C deficiency is a rare variant form of Gaucher disease caused by impaired Sap C expression or accelerated… 
2011
2011
Efficient one-step chromatographic purification and functional characterization of recombinant human Saposin C.
2011
2011
Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells
We previously demonstrated that ectopic expression of neurotrophic peptide (NP) derived from saposin C promotes androgen receptor… 
2010
2010
A Stretch of 17 Amino Acids in the Prosaposin C Terminus Is Critical for Its Binding to Sortilin and Targeting to Lysosomes
Prosaposin, the precursor of four lysosomal cofactors required for the hydrolysis of sphingolipids, is transported to the… 
2008
2008
Molecular Dynamics Simulation of Saposin C-Membrane Binding
To understand the mechanism of Saposin C-membrane binding at low pH, several molecular dynamics (MD) simulations of saposin C… 
2008
2008
Prosaposin is an AR‐target gene and its neurotrophic domain upregulates AR expression and activity in prostate stromal cells
Recent studies have introduced prosaposin (PSAP) as a pleiotrophic growth factor for prostate cancer (PCa). We have previously… 
2007
2007
Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.
Saposins (A, B, C and D) are approximately 80 amino acid stimulators of glycosphingolipid (GSL) hydrolases that derive from a… 
2005
2005
The N370S (Asn370-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C.
The properties of the endolysosomal enzyme GCase (glucosylceramidase), carrying the most prevalent mutation observed in Gaucher… 
1998
1998
Secondary structure and limited proteolysis give experimental evidence that the precursor of pulmonary surfactant protein B contains three saposin‐like domains
Highly Cited
1995
Highly Cited
1995
Structural Analysis of Saposin C and B
Saposins A, B, C, and D are a group of homologous glycoproteins derived from a single precursor, prosaposin, and apparently… 
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