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saposin

National Institutes of Health

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Saposins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Two short antimicrobial peptides derived from prosaposin-like proteins in the starry flounder (Platichthys stellatus).
2017
2017
Saposin-Lipoprotein Scaffolds for Structure Determination of Membrane Transporters.
Highly Cited
2015
Highly Cited
2015
Ambroxol-induced rescue of defective glucocerebrosidase is associated with increased LIMP-2 and saposin C levels in GBA1 mutant Parkinson's disease cells
2014
2014
Gaucher disease due to saposin C deficiency is an inherited lysosomal disease caused by rapidly degraded mutant proteins.
Saposin (Sap) C is an essential cofactor for the lysosomal degradation of glucosylceramide (GC) by glucosylceramidase (GCase) and… 
Highly Cited
2012
Highly Cited
2012
Reduced cathepsins B and D cause impaired autophagic degradation that can be almost completely restored by overexpression of these two proteases in Sap C-deficient fibroblasts.
Saposin (Sap) C deficiency, a rare variant form of Gaucher disease, is due to mutations in the Sap C coding region of the… 
Highly Cited
2010
Highly Cited
2010
Saposin C mutations in Gaucher disease patients resulting in lysosomal lipid accumulation, saposin C deficiency, but normal prosaposin processing and sorting.
Gaucher disease (GD) is characterized by accumulation of glucosylceramide (GC) in the cells of monocyte/macrophage system. The… 
Highly Cited
2007
Highly Cited
2007
Non‐neuronopathic Gaucher disease due to saposin C deficiency
Gaucher disease is generally caused by a deficiency of the lysosomal enzyme glucocerebrosidase. The degradation of… 
2003
2003
Interaction of saposin D with membranes: effect of anionic phospholipids and sphingolipids.
Saposin (Sap) D is an endolysosomal protein that, together with three other similar proteins, Sap A, Sap B and Sap C, is involved… 
2001
2001
Saposin D Solubilizes Anionic Phospholipid-containing Membranes*
Saposin (Sap) D is a late endosomal/lysosomal small protein, generated together with three other similar proteins, Sap A, B, and… 
Highly Cited
1998
Highly Cited
1998
Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor‐related protein (LRP)
Sphingolipid activator proteins SAP‐A, ‐B, ‐C and ‐D (also called saposins) are generated by proteolytic processing from a 73 kDa… 
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