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Saposins

Known as: Saposins [Chemical/Ingredient], Testibumin 
A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred… 
National Institutes of Health

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Combined Saposin DeficiencyKRABBE DISEASE, ATYPICAL, DUE TO SAPOSIN A DEFICIENCYMetachromatic Leukodystrophy due to Saposin B DeficiencyPSAP protein, human
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Combined saposin C and D deficiencies in mice lead to a neuronopathic phenotype, glucosylceramide and alpha-hydroxy ceramide accumulation, and altered prosaposin trafficking.
Saposins (A, B, C and D) are approximately 80 amino acid stimulators of glycosphingolipid (GSL) hydrolases that derive from a… 
2000
2000
Saposins A, B, C, and D in plasma of patients with lysosomal storage disorders.
BACKGROUND Early diagnosis of lysosomal storage disorders (LSDs), before the onset of irreversible pathology, will be critical… 
Highly Cited
1995
Highly Cited
1995
Structural Analysis of Saposin C and B
Saposins A, B, C, and D are a group of homologous glycoproteins derived from a single precursor, prosaposin, and apparently… 
Highly Cited
1994
Highly Cited
1994
Functional human saposins expressed in Escherichia coli. Evidence for binding and activation properties of saposins C with acid beta-glucosidase.
Small (80-amino acid) glycoproteins or saposins are important for the in vivo function of several lysosomal hydrolases. Four… 
1993
1993
Nonciliated cells of the rat efferent ducts endocytose testicular sulfated glycoprotein‐1 (SGP‐1) and synthesize SGP‐1 derived saposins
Sertoli cell sulfated glycoprotein‐1 (SGP‐1) is a heavily glycosylated and sulfated 70 kDa protein that is secreted into the… 
Highly Cited
1991
Highly Cited
1991
Isolation and characterization of prosaposin from human milk.
1991
1991
Identification and purification of a human Sertoli cell-secreted protein (hSCSP-80) stimulating Leydig cell steroid biosynthesis.
Human Sertoli cells in vitro secrete a factor that stimulates steroid biosynthesis in purified human and rat Leydig cells as well… 
1989
1989
Albumin, a biologically active protein acting on Leydig cells
1987
1987
The distribution of rat testibumin in the male reproductive tract.
A glycoprotein, designated CMB-1, has been identified in media from Sertoli cell-enriched cultures that increases in… 
1986
1986
Rat testicular testibumin is a protein responsive to follicle stimulating hormone and testosterone that shares immunodeterminants with albumin.
During a search for hormonally responsive products in media from Sertoli cell enriched cultures, a major follicle stimulating… 
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