Saposins

Known as: Saposins [Chemical/Ingredient], Testibumin 
A group of four homologous sphingolipid activator proteins that are formed from proteolytic cleavage of a common protein precursor molecule referred… (More)
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Saposins or sphingolipid activator proteins (SAPs) are small, nonenzymatic glycoproteins that are ubiquitously present in… (More)
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Highly Cited
2007
Highly Cited
2007
CD1d molecules bind lipid antigens in the endocytic pathway, and access to the pathway is important for the development of CD1d… (More)
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2006
2006
Saposins A and C are sphingolipid activator proteins required for the lysosomal breakdown of galactosylceramide and… (More)
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2006
2006
Saposins are lipid-binding and membrane-perturbing glycoproteins of the mammalian lysosomes involved in sphingolipid and membrane… (More)
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Highly Cited
2004
Highly Cited
2004
CD1d is a major histocompatibility complex (MHC) class I–related molecule that functions in glycolipid antigen presentation to… (More)
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1995
1995
Saposins A, B, C, and D are small lysosomal glycoproteins released by proteolysis from a single precursor polypeptide, prosaposin… (More)
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1994
1994
Small (80-amino acid) glycoproteins or saposins are important for the in vivo function of several lysosomal hydrolases. Four… (More)
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Highly Cited
1993
Highly Cited
1993
We have isolated storage cytosomes from brain tissue of patients with infantile neuronal ceroid-lipofuscinosis. The purified… (More)
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1990
1990
Activity of lysosomal glucosylceramidase is stimulated by two small glycoproteins, saposin A and C, which are, together with two… (More)
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1990
1990
Saposins are small, heat-stable glycoproteins required for the hydrolysis of sphingolipids by specific lysosomal hydrolases… (More)
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