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sanfetrinem

An orally available tricyclic beta-lactam (trinem) antibiotic, with broad-spectrum activity against gram-positive and gram-negative bacteria… 
National Institutes of Health

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Related topics

3 relations

Narrower (2)

GV 104326GV 118819X

Broader (1)

Lactams

Papers overview

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2010
2010
Synthesis of a key intermediate of β-lactam of sanfetrinem
The key intermediate 1,used for the preparation of a new classical β-lactam of sanfetrinem cilexetil,was obtained via eight steps… 
2009
2009
Permeability of a novel beta-lactamase inhibitor LK-157 and its ester prodrugs across rat jejunum in vitro.
OBJECTIVES LK-157 is a novel 10-ethylidene tricyclic carbapenem that resembles the structure of the broad-spectrum antibiotic… 
2006
2006
[Sanfetrinem, the member of trinems--in vitro activity against Klebsiella pneumoniae producing ESBL].
Sanfetrinem is the first member of tricyclic beta-lactams (trinems) which can be administered orally as a hexatil ester. His… 
2002
2002
SmI(2)-mediated cyclizations of derivatized beta-lactams for the highly diastereoselective construction of functionalized prolines.
A series of C4-keto-functionalized 1-[(benzoyloxy)(ethoxycarbonyl)methyl]-2-azetidinones were prepared and studied for their… 
2002
2002
Evaluation of the role of intestinal and liver metabolism in the conversion of two different ester prodrugs of sanfetrinem to the parent drug in vitro and in vivo using different rat tissues and a…
2001
2001
Development and validation of a column-switching high-performance liquid chromatographic method for the determination of sanfetrinem in rat and dog plasma by direct injection.
2001
2001
Development and validation of a high-performance liquid chromatography-tandem mass spectrometry assay for the determination of sanfetrinem in human plasma.
1998
1998
In-vitro activity of sanfetrinem against isolates of Streptococcus pneumoniae and Staphylococcus aureus.
The activity of sanfetrinem (previously GV104326), was assessed against 168 isolates of Streptococcus pneumoniae and 90 isolates… 
1998
1998
Interactions of beta-lactamases with sanfetrinem (GV 104326) compared to those with imipenem and with oral beta-lactams.
Sanfetrinem is a trinem beta-lactam which can be administered orally as a hexatil ester. We examined whether its beta-lactamase… 
1997
1997
Susceptibility testing of fastidious organisms.
The NCCLS has published guidelines for the susceptibility testing of fastidious organisms. 1 Following these guidelines for the… 
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