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rupintrivir

Known as: ethyl-3-((5'-methylisoxazole-3'-carbonyl)-Valpsi(COCH2)Phe(4-F)-(pyrrol-Ala))propenoate, Ruprintrivir, (trans-(4S,2'R,5'S,3''S)-4-(2'-4-(4-fluorobenzyl)-6'-methyl-5'-((5''-methylisoxazole)-3''-carbonylamino)-4-oxoheptanoylamino))-5-(2''-oxopyrrolidin-3'''-yl)pent-2-enoic acid ethyl ester 
A peptidomimetic inhibitor with activity against human rhinoviruses. Rupintrivir is an irreversible 3C protease inhibitor which blocks processing of… 
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (1)

AG7088

Broader (2)

IsoxazolesPyrrolidinones

Papers overview

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2017
2017
Antiviral Activity of Itraconazole against Echovirus 30 Infection In Vitro
Objectives Echovirus 30 is a major cause of meningitis in children and adults. The aim of this study was to investigate whether… 
2017
2017
Transcriptomic analyses reveal anti-viral responses of epithelial cells and multiple immune cell types in HRV infected human lung tissue
Human rhinovirus (HRV) is a main cause of airway infections and a major risk factor of exacerbations in asthma and COPD… 
2016
2016
Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2–P4 study
Abstract Enterovirus 71 (EV71) is a highly infectious pathogen primarily responsible for Hand, Foot, and Mouth Disease… 
2016
2016
Responses to rhinovirus infection in human lung slices are reduced by rupintrivir
Human rhinovirus (HRV) is a main cause of the common cold in humans, and for asthmatics a major risk factor for exacerbations… 
2013
2013
Rapid and convenient assays to assess potential inhibitory activity on in vitro hepatitis A replication.
Review
2013
Review
2013
Multiple Classes of Antiviral Agents Exhibit In Vitro Activity 4 against Human Rhinovirus Type C 5 6
19 Human rhinovirus type C (HRV-C) is a newly discovered enterovirus species 20 frequently associated with exacerbation of asthma… 
2009
2009
Real-Time Monitoring of Human Enterovirus ( HEV )-Infected Cells and Anti-HEV 3 C Protease Potency by Fluorescence Resonance Energy Transfer †
Real-Time Monitoring of Human Enterovirus (HEV)-Infected Cells and Anti-HEV 3C Protease Potency by Fluorescence Resonance Energy… 
2005
2005
Lack of Respiratory and Contact Sensitizing Potential of the Intranasal Antiviral Drug Candidate Rupintrivir (AG7088): A Weight-of-the-Evidence Evaluation
Rupintrivir, also known as AG7088, is a small molecule 3C protease inhibitor designed to target human rhinovirus as a potential… 
1982
1982
Protease Inhibitor Rupintrivir , a Novel Human Rhinovirus 3 C Broad-Spectrum Antiviral Activity of Rhinovirus 3 C Protease Correlates with Conservation of Amino Acids in Human
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