ruffle

Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. [ISBN:0124325653]

Topic mentions per year

Topic mentions per year

1936-2017
0102019362016

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2007
2007
The Wiskott-Aldrich syndrome protein (WASP) family activates the Arp2/3 complex leading to the formation of new actin filaments… (More)
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2007
Highly Cited
2007
Cell motility proceeds by cycles of edge protrusion, adhesion, and retraction. Whether these functions are coordinated by… (More)
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2003
Highly Cited
2003
Cell migration is driven by actin polymerization at the leading edge of lamellipodia, where WASP family verprolin-homologous… (More)
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2002
Highly Cited
2002
The serine/threonine kinase p21-activated kinase 1 (Pak1) controls the actin cytoskeletal and ruffle formation through mechanisms… (More)
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2000
Highly Cited
2000
There are two widely divergent theories about the relation of speech to language. The more conventional view holds that the… (More)
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2000
Highly Cited
2000
The dynamin family of large GTPases has been implicated in the formation of nascent vesicles in both the endocytic and secretory… (More)
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1999
Highly Cited
1999
Synthesis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], a signaling phospholipid, is primarily carried out by… (More)
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1998
Highly Cited
1998
Rac is a Rho-family small GTPase that induces the formation of membrane ruffles. However, it is poorly understood how Rac-induced… (More)
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1993
1993
Treatment with hepatocyte growth factor/scatter factor (HGF/SF) rapidly induced the formation of conspicuous circular ruffles on… (More)
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1988
Highly Cited
1988
One of the earliest effects of platelet-derived growth factor (PDGF) on human fibroblasts in culture is an induction of membrane… (More)
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