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ruboxistaurin

Known as: 13-((dimethylamino)methyl)-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo(e,k)pyrrolo(3,4-h)(1,4,13)oxadiazacyclohexadecene-1,3(2H)-dione, ruboxistaurin [Chemical/Ingredient] 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Diabetic kidney disease (DKD) is a major cause of morbidity and mortality in patients with diabetes mellitus and the leading… Expand
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Highly Cited
2012
Highly Cited
2012
A clear relationship between diabetes and cardiovascular disease has been established for decades. Despite this, the mechanisms… Expand
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Highly Cited
2009
Highly Cited
2009
Background—Heart failure is a common cause of morbidity and mortality in diabetic patients that frequently manifests in the… Expand
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Highly Cited
2009
Highly Cited
2009
Protein kinase (PK)Cα, PKCβ, and PKCγ comprise the conventional PKC isoform subfamily, which is thought to regulate cardiac… Expand
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Review
2007
Review
2007
Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas… Expand
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE To evaluate the safety and efficacy of orally administered ruboxistaurin (RBX) as a mesylate salt in patients with… Expand
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE To evaluate the effect of ruboxistaurin, an orally administered protein kinase C beta (PKC beta) isozyme-selective… Expand
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE Ruboxistaurin selectively inhibits protein kinase C-beta and ameliorates kidney disease in animal models of diabetes… Expand
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE The aim of this study was to assess the effects of ruboxistaurin (RBX) mesylate on nerve function and sensory symptoms… Expand
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Highly Cited
2005
Highly Cited
2005
  • K. Tuttle
  • Journal of the American Society of Nephrology…
  • 2005
  • Corpus ID: 22818225
Diabetic nephropathy is one of the most important concerns in nephrology, as well as in medicine at large. Rapidly increasing… Expand
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