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roquinimex

Known as: 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide, 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-, N-Phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide 
A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement… Expand
National Institutes of Health

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2007
2007
Roquinimex is an immunomodulator that can effectively inhibit the development of several autoimmune diseases in animal models… Expand
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2006
2006
5-Chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide (laquinimod, 2) is an oral drug in clinical… Expand
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Highly Cited
2004
Highly Cited
2004
The new orally active drug laquinimod (ABR-215062) was evaluated in experimental autoimmune encephalomyelitis (EAE) in the Lewis… Expand
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2004
2004
Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The… Expand
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Highly Cited
2002
Highly Cited
2002
A new orally active drug, laquinimod (ABR-215062), was shown to completely inhibit the development of murine acute experimental… Expand
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Review
2002
Review
2002
The therapy for multiple sclerosis (MS) has changed dramatically over the past decade. Recent immunobiological findings and… Expand
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Highly Cited
2000
Highly Cited
2000
OBJECTIVE To determine whether linomide (roquinimex) is better than placebo in slowing the time to confirmed clinical worsening… Expand
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2000
2000
OBJECTIVE To determine the safety and efficacy of roquinimex (linomide) in the management of relapsing-remitting and secondary… Expand
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2000
2000
The absorption and disposition of roquinimex (Linomide) were studied in four male and two female healthy volunteers. The subjects… Expand
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1998
1998
BACKGROUND Tumor-associated macrophages (TAMs) can either promote angiogenesis (i.e., the formation of new blood vessels) in… Expand
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