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roquinimex

Known as: 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide, 3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-, N-Phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide 
A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement… 
National Institutes of Health

Related topics

Related topics

6 relations

Broader (3)

Angiogenesis InhibitorsHydroxyquinolinesImmunologic Adjuvants

Narrower (3)

LS 2616LinomidePNU-212616

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Drug information resources used by nurse practitioners and collaborating physicians at the point of care in Nova Scotia, Canada: a survey and review of the literature
BackgroundKeeping current with drug therapy information is challenging for health care practitioners. Technologies are often… 
2006
2006
Synthesis and reactivity of laquinimod, a quinoline-3-carboxamide: intramolecular transfer of the enol proton to a nitrogen atom as a plausible mechanism for ketene formation.
5-Chloro-N-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-N-phenyl-3-quinolinecarboxamide (laquinimod, 2) is an oral drug in clinical… 
Highly Cited
2004
Highly Cited
2004
Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.
Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The… 
2003
2003
Roquinimex inhibits dextran sodium sulfate-induced murine colitis
Abstract:Objective: Roquinimex is a modulator of the immune system and has been shown to attenuate induction of several… 
Review
2001
Review
2001
The immunomodulator Linomide: role in treatment and prevention of autoimmune diabetes mellitus.
Review
2001
Review
2001
Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system.
Highly Cited
2000
Highly Cited
2000
Linomide in relapsing and secondary progressive MS
Objective: To determine the safety and efficacy of roquinimex (linomide) in the management of relapsing-remitting and secondary… 
2000
2000
Absorption and disposition including enterohepatic circulation of (14C) roquinimex after oral administration to healthy volunteers
The absorption and disposition of roquinimex (Linomide®) were studied in four male and two female healthy volunteers. The… 
Highly Cited
1998
Highly Cited
1998
Macrophage role in the anti-prostate cancer response to one class of antiangiogenic agents.
BACKGROUND Tumor-associated macrophages (TAMs) can either promote angiogenesis (i.e., the formation of new blood vessels) in… 
1997
1997
Anti-angiogenic treatment with linomide as adjuvant to surgical castration in experimental prostate cancer.
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