Linomide

 
National Institutes of Health

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2 relations
LS 2616

Broader (1)

roquinimex

Papers overview

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Highly Cited
2000
Highly Cited
2000
Linomide in relapsing and secondary progressive MS: part I: trial design and clinical results. North American Linomide Investigators.
OBJECTIVE To determine whether linomide (roquinimex) is better than placebo in slowing the time to confirmed clinical worsening… (More)
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2000
2000
Linomide in the treatment of multiple sclerosis: MRI results from prematurely terminated phase-III trials.
Due to an unexpected increase in serious cardiovascular events in MS patients treated with Linomide, a synthetic immunomodulator… (More)
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1997
1997
Potentiation of the antiangiogenic ability of linomide by androgen ablation involves down-regulation of vascular endothelial growth factor in human androgen-responsive prostatic cancers.
Linomide is a p.o. active antiangiogenic agent that has been demonstrated to be effective in suppressing the in vivo growth of… (More)
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1996
1996
Antiangiogenic treatment with linomide as chemoprevention for prostate, seminal vesicle, and breast carcinogenesis in rodents.
There are two distinct phases during prostatic carcinogenesis with regard to tumor blood vessel development. During the first or… (More)
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Highly Cited
1995
Highly Cited
1995
Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
In a number of experimental systems in which lymphocyte depletion was induced by apoptosis-inducing manipulations, no apoptotic… (More)
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1995
1995
Linomide reduces the rate of active lesions in relapsing-remitting multiple sclerosis
The synthetic immunomodulator Linomide, a quinoline-3-carboxamide, has a profound inhibitory influence in several experimental… (More)
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1995
1995
Linomide inhibits angiogenesis, growth, metastasis, and macrophage infiltration within rat prostatic cancers.
Linomide, a quinoline-3-carboxamide, has the ability to inhibit the growth of prostatic cancer in vivo but not in vitro (T… (More)
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1995
1995
Human prostatic cancer cells are sensitive to programmed (apoptotic) death induced by the antiangiogenic agent linomide.
Human prostatic cancer cells have a remarkably low rate of proliferation even when they have metastasized to the bone and have… (More)
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1993
1993
Treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator linomide (quinoline-3-carboxamide).
Linomide is a synthetic immunomodulator that enhances natural killer cell activity and significantly activates several… (More)
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1993
1993
Antiangiogenic effects of the quinoline-3-carboxamide linomide.
Linomide (N-phenylmethyl-1,2-dihydro-4-hydroxyl-1-methyl-2-oxoquinoline-3-carboxa mide) has a reproducible in vivo antitumor… (More)
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