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rolofylline

Known as: 1,3-dipropyl-8-(3-noradamantyl)xanthine, 1,3-dipropyl-8-(tricyclo(3.3.1.0(sup 3,7))non-3-yl)-3,7-dihydro-1h-purine-2,6-dione, 1,3-DNAX 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

DiureticsXanthines

Narrower (2)

KW-3902MK 7418

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
International differences in clinical characteristics, management, and outcomes in acute heart failure patients: better short‐term outcomes in patients enrolled in Eastern Europe and Russia in the…
The implications of geographical variation are unknown following adjustment for hospital length of stay (LOS) in heart failure… 
Highly Cited
2013
Highly Cited
2013
Diuretic response in acute heart failure: clinical characteristics and prognostic significance.
AIM Diminished diuretic response is common in patients with acute heart failure, although a clinically useful definition is… 
Highly Cited
2011
Highly Cited
2011
Early dyspnoea relief in acute heart failure: prevalence, association with mortality, and effect of rolofylline in the PROTECT Study.
AIMS Dyspnoea and pulmonary and/or peripheral congestion are the most frequent manifestations of acute heart failure (AHF) and… 
Highly Cited
2007
Highly Cited
2007
The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance.
Highly Cited
2006
Highly Cited
2006
Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3‐cd]purinediones
The structure–activity relationships of xanthine derivatives related to the adenosine A1 receptor antagonists 8‐cyclopentyl‐1,3… 
Highly Cited
2001
Highly Cited
2001
Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.
Highly Cited
1994
Highly Cited
1994
A1 receptor mediated myocardial infarct size reduction by endogenous adenosine is exerted primarily during ischaemia.
OBJECTIVE The aim was to test the hypothesis that A1 receptor mediated cardioprotection by endogenous adenosine is exerted during… 
Highly Cited
1993
Highly Cited
1993
Diuretic and renal protective effects of 8-(noradamantan-3-yl)-1,3-dipropylxanthine (KW-3902), a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism.
KW-3902 [8-(noradamantan-3-yl)-1,3-dipropylxanthine] is a novel potent and selective adenosine A1-receptor antagonist. In… 
Highly Cited
1992
Highly Cited
1992
Adenosine A1 antagonists. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure.
Diuretic activities of xanthine or nonxanthine adenosine antagonists and their ameliorative effects against glycerol-induced… 
Highly Cited
1992
Highly Cited
1992
8-Polycycloalkyl-1,3-dipropylxanthines as potent and selective antagonists for A1-adenosine receptors.
With the aim of characterizing the hydrophobic interactions between xanthines and the A1 receptor site, 1,3-dipropyl-8… 
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