The disconnect between phase II and phase III trials of drugs for heart failure

Abstract

Hospitalization for heart failure (HF) is a clinical entity associated with high postdischarge morbidity and mortality, yet few therapies are available to improve outcomes in patients with this condition. In the past decade, large phase III studies of HF treatments have failed to demonstrate drug efficacy, safety, or both, despite encouraging results from… (More)
DOI: 10.1038/nrcardio.2012.181

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