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retroviral 3' processing activity

Known as: 3' processing reaction, 3'-processing activity 
The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls. [PMID… 
National Institutes of Health

Papers overview

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2015
2015
Characterization of the Drug Resistance Profiles of Integrase Strand Transfer Inhibitors in Simian Immunodeficiency Virus SIVmac239
ABSTRACT We previously showed that the simian immunodeficiency virus SIVmac239 is susceptible to human immunodeficiency virus… 
2007
2007
Single amino acid substitution in HIV‐1 integrase catalytic core causes a dramatic shift in inhibitor selectivity
Highly Cited
2004
Highly Cited
2004
Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro.
Styrylquinoline derivatives (SQ) efficiently inhibit the 3'-processing activity of integrase (IN) with IC50 values of between 0.5… 
Highly Cited
2004
Highly Cited
2004
Nuclear Import of HIV-1 Integrase Is Inhibited in Vitro by Styrylquinoline Derivatives
Nuclear import of HIV-1 preintegration complexes (PICs) allows the virus to infect nondividing cells. Integrase (IN), the PIC… 
2004
2004
In Vitro Processing of the 3′-Overhanging DNA in the Postcleavage Complex Involved in V(D)J Joining
ABSTRACT The postcleavage complex involved in V(D)J joining is known to possess a transpositional strand transfer activity, whose… 
1999
1999
Major and minor groove contacts in retroviral integrase-LTR interactions.
The 3'-processing activities of HIV-1, HTLV-2, and M-MuLV integrases (INs) with their corresponding U5 end of the viral DNA… 
1997
1997
3' processing of human pre-U2 small nuclear RNA: a base-pairing interaction between the 3' extension of the precursor and an internal region
The spliceosomal small nuclear RNAs U1, U2, U4, and U5 are transcribed by RNA polymerase II as precursors with extensions at… 
1995
1995
Characterization of Mg(2+)-dependent 3'-processing activity for human immunodeficiency virus type 1 integrase in vitro: real-time kinetic studies using fluorescence resonance energy transfer.
Human immunodeficiency virus type 1 integrase (HIV-1 IN) catalyzes the integration of HIV-1 DNA into the host chromosome. In… 
1994
1994
Methylphosphonodiester substitution near the conserved CA dinucleotide in the HIV LTR alters both extent of 3'-processing and choice of nucleophile by HIV-1 integrase.
We present evidence suggesting that the 3'-processing activity of HIV-1 integrase is dramatically affected by electrostatic and… 
1991
1991
Unusual compartmentalisation of mouse U7 small nuclear transcripts in Xenopus oocytes.
Small nuclear RNAs are generally transcribed as precursors in the eukaryotic nucleus which then rapidly enter the cytoplasm. In… 
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