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A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease
SUMMARY Hantaviruses are enzootic viruses that maintain persistent infections in their rodent hosts without apparent disease symptoms. The spillover of these viruses to humans can lead to one of twoExpand
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Treatment of hantavirus pulmonary syndrome.
Viruses in the genus Hantavirus can cause one of two serious illnesses when transmitted from rodents to humans: hemorrhagic fever with renal syndrome (HFRS) or hantavirus pulmonary syndrome (HPS). OfExpand
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Structural Studies of Hantaan Virus
ABSTRACT Hantaan virus is the prototypic member of the Hantavirus genus within the family Bunyaviridae and is a causative agent of the potentially fatal hemorrhagic fever with renal syndrome. TheExpand
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Replication of hantaviruses.
Hantaviruses have a genome consisting of three segments of negative-sense, single-strand RNA (reviewed in Schmaljohn 1996a). The large (L), medium (M), and small (S) genomic segments, or vRNAs, codeExpand
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Dynein-Dependent Transport of the Hantaan Virus Nucleocapsid Protein to the Endoplasmic Reticulum-Golgi Intermediate Compartment
ABSTRACT In contrast to most negative-stranded RNA viruses, hantaviruses and other viruses in the family Bunyaviridae mature intracellularly, deriving the virion envelope from the endoplasmicExpand
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Ribavirin Causes Error Catastrophe during Hantaan Virus Replication
ABSTRACT Except for ribavirin, no other antiviral drugs for treating hantaviral diseases have been identified. It is well established that ribavirin will inhibit the production of infectious HantaanExpand
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A cell-based luminescence assay is effective for high-throughput screening of potential influenza antivirals.
The spread of highly pathogenic avian influenza across geographical and species barriers underscores the increasing need for novel antivirals to compliment vaccination and existing antiviralExpand
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Ebola Virus VP30 Is an RNA Binding Protein
ABSTRACT The Ebola virus (EBOV) genome encodes for several proteins that are necessary and sufficient for replication and transcription of the viral RNAs in vitro; NP, VP30, VP35, and L. VP30 acts inExpand
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High prevalence of hantavirus infection in Indian communities of the Paraguayan and Argentinean Gran Chaco.
Serologic evidence of past infection with a Sin Nombre-like hantavirus(es) was demonstrated in 78 (40.4%) of 193 Indians living in western Paraguay and in 38 (17.1%) of 222 Indians inhabiting theExpand
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Characterization of the Hantaan Nucleocapsid Protein-Ribonucleic Acid Interaction*
The nucleocapsid (N) protein functions in hantavirus replication through its interactions with the viral genomic and antigenomic RNAs. To address the biological functions of the N protein, it wasExpand
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