Skip to search formSkip to main contentSkip to account menu

remikiren

Known as: (S)-alpha-((S)-alpha-((t-butylsulfonyl)methyl)hydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)imidazole-4-propionamide, (alphaS)-alpha-((alphaS)-alpha-((tert-Butylsulfonyl)methyl)hydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl)imidazole-4-propionamide 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Antihypertensive AgentsImidazolesProtease Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
The impact of accurate mass measurements using quadrupole/time-of-flight mass spectrometry on the characterisation and screening
Atmospheric pressure ionisation quadrupole/ time-of-flight mass spectrometry was used to perform accurate mass measurements on… 
1996
1996
Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates.
1. An hplc method with fluorescence derivatization was developed for the quantification of remikiren in plasma (limit of… 
Highly Cited
1996
Highly Cited
1996
Does the renin-angiotensin system determine the renal and systemic hemodynamic response to sodium in patients with essential hypertension?
Many patients with essential hypertension respond to a high dietary sodium intake with a rise in blood pressure. Experimental… 
1996
1996
Excretion and metabolism of remikiren, a potent orally active inhibitor of primate renin.
1. Following intravenous administration of 14C-remikiren to the male rat, 78% of the administered radioactivity was recovered in… 
1995
1995
Responses to an Orally Active Renin Inhibitor, Remikiren (Ro 42–5892), After Controlled Salt Depletion in Humans
Summary The biological effects of dose-dependent inhibition of renin have rarely been extensively studied after oral (p.o… 
1994
1994
Blood pressure effects of acute intravenous renin or oral angiotensin converting enzyme inhibition in essential hypertension
Objective To assess the participation of the renin-angiotensin system in the blood pressure regulation of essential hypertensive… 
1994
1994
Vascular renin in the guinea pig. Suppression by the renin inhibitor remikiren.
Angiotensin I and II are generated by the vascular wall. Whether this generation depends on renin or on other enzymes is debated… 
1993
1993
Hemodynamics, biochemical effects, and pharmacokinetics of the renin inhibitor remikiren in healthy human subjects
Introduction: Remikiren (Ro 42‐5892) is a potent and specific inhibitor of human renin in vitro. Its in vivo action on plasma… 
1993
1993
Multiple dose pharmacokinetics and concentration effect relationship of the orally active renin inhibitor remikiren (Ro 42-5892) in hypertensive patients.
1 Three double-blind, randomized, placebo controlled, multiple oral dose studies in patients with mild to moderate hypertension… 
1993
1993
Comparative effects of three different potent renin inhibitors in primates.
The goal of the present study was to compare the effects of three potent reference renin inhibitors (remikiren, CGP 38560A, and… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)