rasfonin
National Institutes of Health
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OBJECTIVE
To investigate the effects of rasfonin, a fungal secondary metabolite, on the proliferation and migration of…
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3), is a critical enzyme for glycolysis and highly expressed…
Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation…
ABSTRACT Rasfonin (A304) is a fungal natural product isolated from the fermentation substrate of Talaromyces sp. 3656-A1, which…
ABSTRACT Two major protein quality control mechanisms exist in eukaryotic cells, the ubiquitin-proteasome system (UPS) and the…
Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the…
Rasfonin is a novel 2-pyrone derivative reported to induce apoptosis in ras-dependent cells. In this study, its effects on ras…
Rasfonin (A304) was originally extracted from the Taleromyces sp. and Trichurus terrophilus, and was found to have the inhibitory…
apoptosis inducers in ras-dependent cells are expected to be new anticancer agents against cells expressing constitutively active…