rRNA processing

To better understand yeast ribosome synthesis, we developed techniques for the rapid harvesting and analysis of metabolically… (More)

MicroRNAs (miRNAs) control cell proliferation, differentiation and fate through modulation of gene expression by partially base… (More)

It has become clear that in Saccharomyces cerevisiae the transcription of ribosomal protein genes, which makes up a major… (More)

Sequential events in macromolecular biosynthesis are often elegantly coordinated. The small ribosomal subunit (SSU) processome is… (More)

Many or all of the sites of pseudouridine (Psi) formation in eukaryotic rRNA are selected by site-specific base-pairing with… (More)

The eukaryotic 25 S, 18 S, and 5.8 S rRNAs are synthesized as a single transcript with two internal transcribed spacers (ITS1 and… (More)

The m6(2)A1779m6(2)A1780 dimethylation at the 3' end of the small subunit rRNA has been conserved in evolution from bacteria to… (More)

We have generated temperature-sensitive lethal point mutations in the small nucleolar RNA-associated protein fibrillarin (encoded… (More)

Among the few proteins of the eukaryotic nucleolus that have been characterized, four proteins, nucleolin, fibrillarin, SSB1 and… (More)

The yeast snoRNP protein, NOP1, is structurally and functionally homologous to vertebrate fibrillarin and is essential for… (More)