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Mapping the Human miRNA Interactome by CLASH Reveals Frequent Noncanonical Binding
RNA Degradation by the Exosome Is Promoted by a Nuclear Polyadenylation Complex
The Exosome: A Conserved Eukaryotic RNA Processing Complex Containing Multiple 3′→5′ Exoribonucleases
Functions of the exosome in rRNA, snoRNA and snRNA synthesis
- C. Allmang, J. Kufel, G. Chanfreau, P. Mitchell, E. Petfalski, D. Tollervey
- BiologyThe EMBO journal
- 1 October 1999
It is concluded that the exosome is involved in the processing of many RNA substrates and that different components can have distinct functions.
Ribosome synthesis in Saccharomyces cerevisiae.
The recent, and often surprising, advances in the understanding of ribosome synthesis in the yeast Saccharomyces cerevisiae will underscore the unexpected complexity of eukaryotic ribosomes synthesis.
The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.
- C. Allmang, E. Petfalski, A. Podtelejnikov, M. Mann, D. Tollervey, P. Mitchell
- Biology, ChemistryGenes & development
- 15 August 1999
We previously identified a complex of 3' --> 5' exoribonucleases, designated the exosome, that is expected to play a major role in diverse RNA processing and degradation pathways. Further biochemical…
Nuclear Export of 60S Ribosomal Subunits Depends on Xpo1p and Requires a Nuclear Export Sequence-Containing Factor, Nmd3p, That Associates with the Large Subunit Protein Rpl10p
- O. Gadal, Daniela Strauss, J. Kessl, B. Trumpower, D. Tollervey, E. Hurt
- BiologyMolecular and Cellular Biology
- 15 May 2001
It is concluded that nuclear export of 60S subunits requires the nuclear export sequence-containing nonribosomal protein Nmd3p, which directly binds to the large subunit protein Rpl10p.
The path from nucleolar 90S to cytoplasmic 40S pre‐ribosomes
- T. Schäfer, Daniela Strauss, E. Petfalski, D. Tollervey, E. Hurt
- BiologyThe EMBO journal
- 17 March 2003
This data provide an initial biochemical map of the pre‐40S ribosomal subunit on its path from the nucleolus to the cytoplasm, which involves fewer changes in composition than seen during 60S biogenesis.
Coding-Sequence Determinants of Gene Expression in Escherichia coli
In this analysis, mRNA folding and associated rates of translation initiation play a predominant role in shaping expression levels of individual genes, whereas codon bias influences global translation efficiency and cellular fitness.