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pyrithione

Known as: 1-hydroxypyridine-2-thione, 1-hydroxy- 2(1H)-pyridinethione, N-hydroxypyridine-2-thione 
A fungistatic and antimicrobial derivative of aspergillic acid. Although the exact mechanism of action remains to be fully elucidated, pyrithione… Expand
National Institutes of Health

Papers overview

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2009
2009
We have discovered two metal ion binding compounds, pyrithione (PT) and hinokitiol (HK), that efficiently inhibit human… Expand
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Highly Cited
2008
Highly Cited
2008
The purpose of this study was to determine whether exogenous zinc prevents cardiac reperfusion injury by targeting the… Expand
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Highly Cited
2008
Highly Cited
2008
To understand the mechanisms of neuronal Zn2+ homeostasis better, experimental data obtained from cultured cortical neurons were… Expand
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Highly Cited
2005
Highly Cited
2005
Extracellular zinc ions are effectors of many signaling pathways in mammalian cells, including the insulin/IGF-1 pathway… Expand
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2004
2004
Abstract 3C-like (3CL) protease is essential for the life cycle of severe acute… Expand
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Highly Cited
2003
Highly Cited
2003
Zinc is an effector of insulin/IGF-1 signaling and has insulinomimetic effects, the molecular basis of which is not understood… Expand
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Highly Cited
2001
Highly Cited
2001
Recent studies have provided evidence that Zn2+ plays a crucial role in ischemia- and seizure-induced neuronal death. However… Expand
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Highly Cited
1994
Highly Cited
1994
The migration of neutrophils through the endothelium at sites of inflammation may be facilitated by oxidant-mediated disruption… Expand
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Highly Cited
1993
Highly Cited
1993
Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)-acetic acid], a membrane-permeant fluorophore specific for Zn(II), was… Expand
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1978
1978
Pyrithione is a general inhibitor of membrane transport processes in fungi. A brief preincubation of Penicillium mycelia with… Expand
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