Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells

@article{Law2003CharacterisationOZ,
  title={Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells},
  author={Wagner Law and E E Kelland and Paul Sharp and Nick J. Toms},
  journal={Neuroscience Letters},
  year={2003},
  volume={352},
  pages={113-116}
}
In the mammalian brain, extracellular Zn(2+) is reported to play a neuromodulatory role and, during acute CNS injury, increased Zn(2+) release may be neurotoxic. Although several recent studies have examined possible mechanisms of neuronal Zn(2+) accumulation, little is known about oligodendroglial Zn(2+) uptake, the focus of the present study. 65Zn(2+) uptake was time-dependent and saturable (K(m)=3.2+/-1.0 microM, V(max)=697.2+/-67.3 pmoles mg protein(-1) 15 min(-1)). Neither kainate (an AMPA… CONTINUE READING

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