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pyrimidine analog

Known as: Pyrimidine Antagonist, analogs pyrimidine 
An antimetabolite that affects the metabolism and utilization of pyrimidines.
National Institutes of Health

Related topics

Related topics

8 relations

Narrower (6)

FlucytosinePyrimidine analogues, antineoplastic antimetabolitesfluoropyrimidinehalopyrimidine
Pyrimidine Analog [EPC]

Broader (1)

nucleobase analog

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
An Uncommon Oro-cutaneous Complication of Systemic 5-fluorouracil- A Case Report
5-fluorouracil is an antineoplastic drug mainly acts by pyrimidine antagonist and classified as an antimetabolite. There are few… 
2011
2011
Determination of 5-fluorouracil and dihydrofluorouracil levels by using a liquid chromatography–tandem mass spectrometry method for evaluation of dihydropyrimidine dehydrogenase enzyme activity
Purpose5-Fluorouracil (5-FU), acting as a pyrimidine antagonist, is a major chemotherapy drug used for the treatment of tumors… 
2005
2005
New insights in pyrimidine antagonist chemotherapy: the role of pharmacokinetics and pharmacogenetics
Is de werking van een antikankermedicijn bij een patient genetisch bepaald? En hoe gedraagt zo’n middel zich in het lichaam? Jan… 
Review
2002
Review
2002
Hypersensitivity pneumonitis in advanced non-small-cell lung cancer patients receiving gemcitabine and paclitaxel: report of two cases and a review of the literature.
Gemcitabine (2'-2'-difluorodeoxycytidine) is a recently developed pyrimidine antagonist that is structurally related to… 
1997
1997
Effects of folic and folinic acids in the activities of cycloguanil and WR99210 against Plasmodium falciparum in erythrocytic culture.
The in-vitro effects of folinic acid on the antimalarial activities of the triazine antifolates, cycloguanil and WR99210, were… 
Review
1994
Review
1994
Mechanism-Based Inhibitors of Deoxythymidine Monophosphate Synthesis as Antineoplastic Agents
1992
1992
5-Fluorouracil: Schedule Optimization in Metastatic Colorectal Cancer
Initially synthesized as a pyrimidine antagonist over three decades ago, the fluorinated pyrimidine, 5-fluorouracil (FUra), has… 
1987
1987
Effect of deoxycytidine on the in vitro response of human leukemia cells to inhibitors of de novo pyrimidine biosynthesis
SummaryThe effect of high concentrations of exogenous dCyd on the growth inhibitory properties of several inhibitors of de novo… 
1985
1985
Differential effect of deoxycytidine on pyrimidine antagonist mediated growth suppression in normal versus leukemic human myeloid progenitor cells
1961
1961
Advanced neoplastic disease. Treatment with 5-fluorouracil and irradiation.
One hundred and twelve patients with far advanced, inoperable neoplastic disease were treated by a method utilizing the… 
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