fluoropyrimidine

Known as: fluoropyrimidines 
Any fluoropyrimidine-based agent with potential antineoplastic activity. As an antimetabolite, a fluoropyrimidine interferes with pyrimidine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2017
05010015019602017

Papers overview

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Highly Cited
2013
Highly Cited
2013
The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. Detoxifying metabolism… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE The Avastin in Gastric Cancer (AVAGAST) trial was a multinational, randomized, placebo-controlled trial designed to… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Fluoropyrimidine-based chemotherapy plus the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab is… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE To determine whether adding cetuximab to irinotecan prolongs survival in patients with metastatic colorectal cancer (mCRC… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE To evaluate the safety and efficacy of three oxaliplatin and fluoropyrimidine regimens, with or without bevacizumab, as… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Advanced gastric cancer can respond to S-1, an oral fluoropyrimidine. We tested S-1 as adjuvant chemotherapy in… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Cetuximab, an IgG1 chimeric monoclonal antibody against epidermal growth factor receptor (EGFR), has activity against… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Colorectal cancer is the second leading cause of cancer mortality in the United States. Antiangiogenic therapy with… (More)
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Highly Cited
1998
Highly Cited
1998
Capecitabine (N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine) is a novel oral fluoropyrimidine carbamate, which is converted to 5… (More)
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Highly Cited
1998
Highly Cited
1998
S-1 is a novel oral anticancer drug, composed of tegafur (FT), gimestat (CDHP) and otastat potassium (Oxo) in a molar ratio of 1… (More)
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