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pyragonicin

National Institutes of Health

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2 relations

Broader (2)

Fatty AlcoholsLactones

Papers overview

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2010
2010
The relationship between the molecular structure of natural acetogenins and their inhibitory activities which affect DNA polymerase, DNA topoisomerase and human cancer cell growth.
Acetogenins from the Annonaceous plant are a fatty acid-derived natural product. Chemically synthesized natural acetogenins, such… 
2008
2008
Pyranicin, a non-classical annonaceous acetogenin, is a potent inhibitor of DNA polymerase, topoisomerase and human cancer cell growth.
This report describes the inhibitory activities of the natural and non-natural acetogenins [mucocin (compound 1), jimenezin… 
2006
2006
Convergent synthesis of pyragonicin.
This paper describes a second-generation synthesis of an antitumor tetrahydropyran (THP) acetogenin, pyragonicin. The key step… 
2006
2006
Divergence en route to nonclassical annonaceous acetogenins. Synthesis of pyranicin and pyragonicin.
Syntheses of the nonclassical annonaceous acetogenins, pyranicin, and pyragonicin from common late-stage intermediates are… 
2005
2005
Total synthesis of the proposed structure for pyragonicin.
[structure: see text] The total synthesis of acetogenin 1 reported for pyragonicin and its 10-epimer 32 is described. The common… 
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