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- Publications
- Influence
A mushroom fruiting body-inducing substance inhibits activities of replicative DNA polymerases.
- Y. Mizushina, L. Hanashima, +6 authors K. Sakaguchi
- Biology, Medicine
- Biochemical and biophysical research…
- 10 August 1998
We found and isolated two natural products in the extract from a basidiomycete, Ganoderma lucidum, as eukaryotic DNA polymerase inhibitors. The compounds were identified as cerebrosides,… Expand
Sulfoquinovosyldiacylglycerol, KM043, a new potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1 from a marine red alga, Gigartina tenella.
- K. Ohta, Y. Mizushina, +5 authors K. Sakaguchi
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 15 April 1998
A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3')-1',2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as… Expand
DNA polymerase γ inhibition by vitamin K3 induces mitochondria‐mediated cytotoxicity in human cancer cells
- R. Sasaki, Y. Suzuki, +7 authors Y. Mizushina
- Biology, Medicine
- Cancer science
- 1 May 2008
Among the vitamin K (VK) compounds, VK3 exhibits distinct cytotoxic activity in cancer cells and is thought to affect redox cycling; however, the underlying mechanisms remain unclear. Here we… Expand
Suppressive effects of Amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression.
- Mi-Jin Yim, M. Hosokawa, Y. Mizushina, H. Yoshida, Yasunori Saito, K. Miyashita
- Chemistry, Medicine
- Journal of agricultural and food chemistry
- 16 February 2011
Fucoxanthin is converted to fucoxanthinol and amarouciaxanthin A in mice. It was previously reported that fucoxanthinol attenuated the adipogenesis of 3T3-L1 cells. However, the effects of… Expand
An ergosterol peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on DNA polymerase beta.
- Y. Mizushina, I. Watanabe, +10 authors K. Sakaguchi
- Biology, Medicine
- Biological & pharmaceutical bulletin
- 15 May 1998
As described previously (Mizushina Y., Tanaka N., Yagi H., Kurosawa T., Onoue M., Seto H., Horie T., Aoyagi N., Yamaoka M., Matsukage A., Yoshida S., and Sakaguchi K., Biochim. Biophys. Acta, 1308,… Expand
Effects of glycolipids from spinach on mammalian DNA polymerases.
- C. Murakami, T. Kumagai, +9 authors Y. Mizushina
- Biology, Medicine
- Biochemical pharmacology
- 15 January 2003
We purified the major glycolipids in the class of monogalactosyl diacylglycerol (MGDG), digalactosyl diacylglycerol (DGDG) and sulfoquinovosyl diacylglycerol (SQDG) from a green vegetable, spinach… Expand
Monoacetylcurcumin strongly regulates inflammatory responses through inhibition of NF-kappaB activation.
- M. Nishida, S. Nishiumi, +10 authors M. Yoshida
- Biology, Medicine
- International journal of molecular medicine
- 1 May 2010
Curcumin, a component of turmeric (Curcuma longa), is known to exert a variety of biological functions including anti-inflammatory activity. We examined the inhibitory effects of chemically… Expand
Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete, Ganoderma lucidum.
- Y. Mizushina, N. Takahashi, +5 authors K. Sakaguchi
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 September 1999
Terpenoids, 1, 2 and 3, which selectively inhibit eukaryotic DNA polymerase activities, were isolated from the fruiting body of a basidiomycete, Ganoderma lucidum, and their structures were… Expand
Dehydroaltenusin, a Mammalian DNA Polymerase α Inhibitor*
- Y. Mizushina, S. Kamisuki, +10 authors K. Sakaguchi
- Biology, Medicine
- The Journal of Biological Chemistry
- 27 October 2000
Dehydroaltenusin was found to be an inhibitor of mammalian DNA polymerase α (pol α) in vitro. Surprisingly, among the polymerases and DNA metabolic enzymes tested, dehydroaltenusin inhibited only… Expand
Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors.
- Y. Mizushina, T. Akihisa, +6 authors H. Yoshida
- Biology, Medicine
- Life sciences
- 9 September 2005
Isosteviol (ent-16-ketobeyeran-19-oic acid) is a hydrolysis product of stevioside, which is a natural sweetener produced in the leaves of Stevia rebaudiana (Bertoni) Bertoni. In this report, we… Expand