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Enzyme screening of crude sponge extracts prioritized a 2005 Papua New Guinea collection of Hyrtios sp. for further study. The… Expand The tetracyclic nucleus of puupehenone, 15-oxopuupehenol and other sesquiterpene–phenol natural products can be assembled… Expand A new synthetic strategy toward puupehenone-related bioactive metabolites from sclareol oxide, based on a Diels-Alder… Expand Puupehenone, a sesquiterpene produced by certain sponges, was selected in the course of a blind screening for new potential… Expand An investigation of the constituents from an Indonesian Hyrtios sponge has provided new insights about the chemistry and biology… Expand To sharpen the search for new lipoxygenase inhibitors, we designed a screen to probe for both potency and selectivity. The assay… Expand A methanol adduct of puupehenone (1), 15alpha-methoxypuupehenol (2), an artifact resulting from the action of MeOH on puupehenone… Expand Abstract Compounds 7–8 , monoterpenic analogues of the marine metabolites puupehenone ( 1 ) and puupehedione ( 2 ), were prepared… Expand The marine natural product puupehenone (1), isolated in good yields from sponges of the genus Hyrtios, has been shown to undergo… Expand