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purinoceptor P2X4

Known as: P2X4 Purinoceptor, P2X4 Receptors, Purinergic, Receptor, P2X4 
A widely distributed purinergic P2X receptor subtype that plays a role in pain sensation. P2X4 receptors found on MICROGLIA cells may also play a… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
&NA; Anti‐nociceptive tolerance to opioids is a well‐described phenomenon, which severely limits the clinical efficacy of opioids… Expand
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Highly Cited
2009
Highly Cited
2009
Microglia in the dorsal horn of the spinal cord are increasingly recognized as being crucial in the pathogenesis of pain… Expand
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Highly Cited
2009
Highly Cited
2009
BackgroundNeuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly… Expand
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Highly Cited
2009
Highly Cited
2009
Opioids, although fundamental to the treatment of pain, are limited in efficacy by side effects including tolerance and… Expand
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Review
2006
Review
2006
  • K. Inoue
  • Pharmacology & therapeutics
  • 2006
  • Corpus ID: 26991516
Microglia play an important role as immune cells in the central nervous system (CNS). Microglia are activated in threatened… Expand
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Highly Cited
2005
Highly Cited
2005
We have used single‐ and double‐labeling immunfluorescence and reverse transcription‐polymerase chain reaction (RT‐PCR) methods… Expand
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Highly Cited
2000
Highly Cited
2000
Ca2+ signaling plays an important role in endothelial cell (EC) responses to shear stress generated by blood flow. Our previous… Expand
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Highly Cited
2000
Highly Cited
2000
Abstract: The rat ATP P2X4 receptor was expressed in Xenopus laevis oocytes to assess the effect of zinc and copper as possible… Expand
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Highly Cited
1999
Highly Cited
1999
Differential Modulation by Copper and Zinc of P2X2 and P2X4 Receptor Function. The modulation by Cu2+ and Zn2+ of P2X2 and P2X4… Expand
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Highly Cited
1998
Highly Cited
1998
The expression of mRNAs for three P2X receptor subtypes (PX21, P2X2, P2X4) in the rat vascular system was studied by in situ… Expand
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