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purinoceptor P2X4

Known as: P2X4 Purinoceptor, P2X4 Receptors, Purinergic, Receptor, P2X4 
A widely distributed purinergic P2X receptor subtype that plays a role in pain sensation. P2X4 receptors found on MICROGLIA cells may also play a… 
National Institutes of Health

Related topics

Related topics

5 relations
In BloodP2RX4 geneaspects of radiation effectsphysiological aspects

Broader (1)

Receptors, Purinergic P2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain
Accumulating evidence indicates that purinergic P2X4 receptors (P2X4R: cation channels activated by extracellular ATP) expressed… 
Highly Cited
2014
Highly Cited
2014
Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain
In response to neuronal injury or disease, microglia adopt distinct reactive phenotypes via the expression of different sets of… 
Highly Cited
2010
Highly Cited
2010
Inhibition of microglial P2X4 receptors attenuates morphine tolerance, Iba1, GFAP and μ opioid receptor protein expression while enhancing perivascular microglial ED2
Highly Cited
2009
Highly Cited
2009
Morphine Enhances Microglial Migration through Modulation of P2X4 Receptor Signaling
Opioids, although fundamental to the treatment of pain, are limited in efficacy by side effects including tolerance and… 
Highly Cited
2009
Highly Cited
2009
Antidepressants inhibit P2X4 receptor function: a possible involvement in neuropathic pain relief
BackgroundNeuropathic pain is characterized by pain hypersensitivity to innocuous stimuli (tactile allodynia) that is nearly… 
Highly Cited
2008
Highly Cited
2008
Identification of P2X4 receptor transmembrane residues contributing to channel gating and interaction with ivermectin
Ivermectin (IVM), a large macrocyclic lactone, specifically enhances P2X4 receptor-channel function by interacting with residues… 
Highly Cited
2000
Highly Cited
2000
Fluid Shear Stress Activates Ca2+ Influx Into Human Endothelial Cells via P2X4 Purinoceptors
Ca2+ signaling plays an important role in endothelial cell (EC) responses to shear stress generated by blood flow. Our previous… 
Highly Cited
2000
Highly Cited
2000
Zinc and Copper Modulate Differentially the P2X4 Receptor
Abstract: The rat ATP P2X4 receptor was expressed in Xenopus laevis oocytes to assess the effect of zinc and copper as possible… 
Highly Cited
1999
Highly Cited
1999
Differential modulation by copper and zinc of P2X2 and P2X4 receptor function.
Differential Modulation by Copper and Zinc of P2X2 and P2X4 Receptor Function. The modulation by Cu2+ and Zn2+ of P2X2 and P2X4… 
Highly Cited
1998
Highly Cited
1998
Coexpression of mRNAs for P2X1, P2X2 and P2X4 Receptors in Rat Vascular Smooth Muscle: An in situ Hybridization and RT-PCR Study
The expression of mRNAs for three P2X receptor subtypes (PX21, P2X2, P2X4) in the rat vascular system was studied by in situ… 
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