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purine antagonist

Known as: Purine Inhibitors 
An antimetabolite that affects the metabolism and utilization of purines.
National Institutes of Health

Papers overview

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2013
2013
Peripherally selective diphenyl purine antagonist of the CB1 receptor.
Antagonists of the CB1 receptor can be useful in the treatment of several important disorders. However, to date, the only… Expand
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2013
2013
An in silico exploration of the interaction mechanism of pyrazolo[1,5-a]pyrimidine type CDK2 inhibitors.
CDK2, which interacts with cyclin A and cyclin E, is an important member of the CDK family. Having been proved to be associated… Expand
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2011
2011
Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases
Small molecular inhibitors of Cyclin dependent kinases (Cdks) are currently being developed as anticancer therapeutics due to… Expand
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2010
2010
Novel 8-arylated purines as inhibitors of glycogen synthase kinase.
A series of 8-arylated purine derivatives bearing either an aniline or an alkyl amide at position 6 were found to inhibit… Expand
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2010
2010
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
Series of purine and pyrazolo[3,4-d]pyrimidine inhibitors of phosphatidylinositol-3-kinases (PI3K) have been prepared. The… Expand
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2005
2005
Empiric therapy of autoimmune hepatitis with mycophenolate mofetil: comparison with conventional treatment for refractory disease.
GOAL To assess the outcomes of empiric therapy with mycophenolate mofetil in patients with autoimmune hepatitis. BACKGROUND… Expand
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2004
2004
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity… Expand
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1996
1996
Role of the active site gate of glycogen phosphorylase in allosteric inhibition and substrate binding.
The functional role in allosteric regulation of a flexible loop (residues 280-288) located near the active site of muscle… Expand
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1982
1982
In vitro effects of mycophenolic acid and allopurinol against Leishmania tropica in human macrophages.
The possibility that purine inhibitors or analogs might be effective antileishmanial agents led to the determination of the… Expand
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1959
1959
Structure-activity relationships and cross-resistance observed on evaluation of a series of purine analogs against experimental neoplasms.
Extensive efforts by the Burroughs-Wellcome group, the Sloan-Kettering group, and others have led to a considerable knowledge of… Expand
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