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purine antagonist

Known as: Purine Inhibitors 
An antimetabolite that affects the metabolism and utilization of purines.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1947-2014
012319472013

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2013
2013
Peripherally selective diphenyl purine antagonist of the CB1 receptor.
Antagonists of the CB1 receptor can be useful in the treatment of several important disorders. However, to date, the only… (More)
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Review
2006
Review
2006
Purine antagonists for chronic lymphocytic leukaemia.
BACKGROUND Recent trials suggest improved response rates for purine antagonists compared to alkylator-based regimens in the… (More)
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2005
2005
Empiric therapy of autoimmune hepatitis with mycophenolate mofetil: comparison with conventional treatment for refractory disease.
GOAL To assess the outcomes of empiric therapy with mycophenolate mofetil in patients with autoimmune hepatitis. BACKGROUND… (More)
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2003
2003
Mining the genome for combination therapies
 
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1996
1996
2',2'-Difluorodeoxycytidine (gemcitabine) induces apoptosis in myeloma cell lines resistant to steroids and 2-chlorodeoxyadenosine (2-CdA).
The paucity of effective cytotoxic agents for the treatment of steroid resistant multiple myeloma explains the ongoing search for… (More)
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1995
1995
Fatal hepatotoxicity associated with 6-mercaptopurine therapy.
 
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1988
1988
Azathioprine lymphocytotoxicity. Potentially lethal damage by its imidazole derivatives.
The immunosuppressive agent 6-(1-methyl-4-nitroimidazole-5-yl)-thiopurine (azathioprine, AZA) is metabolized to the purine… (More)
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1982
1982
Murine lymphoma L5178Y cells resistant to purine antagonists: differences in cross-resistance to thioguanine-platinum(II) and selenoguanine-platinum(II).
To determine whether the antitumor activities of thioguanine-platinum(II) [TG-Pt(II)] and selenoguanine-platinum(II) [SeG-Pt(II… (More)
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1976
1976
Vitamin B12--folate interrelations.
Megaloblastic anaemia is due to a derangement of DNA synthesis caused by insufficient supply of one or other of the four… (More)
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1959
1959
Structure-activity relationships and cross-resistance observed on evaluation of a series of purine analogs against experimental neoplasms.
Extensive efforts by the Burroughs-Wellcome group, the Sloan-Kettering group, and others have led to a considerable knowledge of… (More)
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