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purine antagonist

Known as: Purine Inhibitors 
An antimetabolite that affects the metabolism and utilization of purines.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases
Small molecular inhibitors of Cyclin dependent kinases (Cdks) are currently being developed as anticancer therapeutics due to… 
2010
2010
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
Review
2006
Review
2006
Purine antagonists for chronic lymphocytic leukaemia.
BACKGROUND Recent trials suggest improved response rates for purine antagonists compared to alkylator-based regimens in the… 
2004
2004
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
2003
2003
N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.
1996
1996
Role of the Active Site Gate of Glycogen Phosphorylase in Allosteric Inhibition and Substrate Binding*
The functional role in allosteric regulation of a flexible loop (residues 280-288) located near the active site of muscle… 
Highly Cited
1959
Highly Cited
1959
Structure-activity relationships and cross-resistance observed on evaluation of a series of purine analogs against experimental neoplasms.
Extensive efforts by the Burroughs-Wellcome group, the Sloan-Kettering group, and others have led to a considerable knowledge of… 
1958
1958
Nucleotide and polynucleotide synthesis in Trypanosoma cruzi. I. Precursors of purine compounds.
Highly Cited
1954
Highly Cited
1954
RESPONSE OF ACUTE LYMPHOCYTIC LEUKEMIAS TO THE PURINE ANTAGONIST 6‐MERCAPTOPURINE
Transformations to resistance or dependence have been obtained in leukemic cells of the mouse by the use of several… 
1951
1951
Some factors influencing nucleic acid purine renewal in the rat.
  • R. Abrams
  • Archives of biochemistry and biophysics
  • 1951
  • Corpus ID: 34011000
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