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purine antagonist
Known as:
Purine Inhibitors
An antimetabolite that affects the metabolism and utilization of purines.
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Anti-angiogenic effects of purine inhibitors of cyclin dependent kinases
J. Liebl
,
V. Kryštof
,
+8 authors
S. Zahler
Angiogenesis
2011
Corpus ID: 23702791
Small molecular inhibitors of Cyclin dependent kinases (Cdks) are currently being developed as anticancer therapeutics due to…
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2010
2010
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
A. Gilbert
,
P. Nowak
,
+10 authors
R. Mallon
Bioorganic & medicinal chemistry letters
2010
Corpus ID: 31415157
Review
2006
Review
2006
Purine antagonists for chronic lymphocytic leukaemia.
M. Steurer
,
G. Pall
,
S. Richards
,
G. Schwarzer
,
J. Bohlius
,
R. Greil
The Cochrane database of systematic reviews
2006
Corpus ID: 25632068
BACKGROUND Recent trials suggest improved response rates for purine antagonists compared to alkylator-based regimens in the…
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2004
2004
Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
W. Pitts
,
Wayne Vaccaro
,
+12 authors
J. Barrish
Bioorganic & medicinal chemistry letters
2004
Corpus ID: 41691893
2003
2003
N-Phenyl-N-purin-6-yl ureas: the design and synthesis of p38alpha MAP kinase inhibitors.
Zehong Wan
,
J. Boehm
,
+4 authors
J. Adams
Bioorganic & medicinal chemistry letters
2003
Corpus ID: 42335167
1996
1996
Role of the Active Site Gate of Glycogen Phosphorylase in Allosteric Inhibition and Substrate Binding*
J. Buchbinder
,
R. Fletterick
The Journal of Biological Chemistry
1996
Corpus ID: 9782898
The functional role in allosteric regulation of a flexible loop (residues 280-288) located near the active site of muscle…
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Highly Cited
1959
Highly Cited
1959
Structure-activity relationships and cross-resistance observed on evaluation of a series of purine analogs against experimental neoplasms.
H. Skipper
,
J. Montgomery
,
J. R. Thomson
,
F. Schabel
Cancer research
1959
Corpus ID: 18504298
Extensive efforts by the Burroughs-Wellcome group, the Sloan-Kettering group, and others have led to a considerable knowledge of…
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1958
1958
Nucleotide and polynucleotide synthesis in Trypanosoma cruzi. I. Precursors of purine compounds.
J. F. Fernandes
,
O. Castellani
Experimental parasitology
1958
Corpus ID: 24945658
Highly Cited
1954
Highly Cited
1954
RESPONSE OF ACUTE LYMPHOCYTIC LEUKEMIAS TO THE PURINE ANTAGONIST 6‐MERCAPTOPURINE
L. Law
,
V. Taormina
,
P. Boyle
Annals of the New York Academy of Sciences
1954
Corpus ID: 36767599
Transformations to resistance or dependence have been obtained in leukemic cells of the mouse by the use of several…
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1951
1951
Some factors influencing nucleic acid purine renewal in the rat.
R. Abrams
Archives of biochemistry and biophysics
1951
Corpus ID: 34011000
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