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purine antagonist

Known as: Purine Inhibitors 
An antimetabolite that affects the metabolism and utilization of purines.
National Institutes of Health

Papers overview

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2011
2011
Small molecular inhibitors of Cyclin dependent kinases (Cdks) are currently being developed as anticancer therapeutics due to… Expand
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2010
2010
Series of purine and pyrazolo[3,4-d]pyrimidine inhibitors of phosphatidylinositol-3-kinases (PI3K) have been prepared. The… Expand
2004
2004
A series of purine based inhibitors of PDE7 has been derived from screening lead 1a. The synthesis, structure-activity… Expand
2003
2003
The design, synthesis and SAR of a series of 2,6,9-trisubstituted purine inhibitors of p38alpha kinase is reported. Synthetic… Expand
1996
1996
The functional role in allosteric regulation of a flexible loop (residues 280-288) located near the active site of muscle… Expand
1982
1982
The possibility that purine inhibitors or analogs might be effective antileishmanial agents led to the determination of the… Expand
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Highly Cited
1959
Highly Cited
1959
Extensive efforts by the Burroughs-Wellcome group, the Sloan-Kettering group, and others have led to a considerable knowledge of… Expand
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1958
1958
Abstract The in vitro synthesis of acid soluble adenine compounds and nucleic acids purines was studied in T. cruzi. The protozoa… Expand
Highly Cited
1954
Highly Cited
1954
Transformations to resistance or dependence have been obtained in leukemic cells of the mouse by the use of several… Expand
1951
1951
  • R. Abrams
  • Archives of biochemistry and biophysics
  • 1951
  • Corpus ID: 34011000
Abstract The utilizations of labeled ammonia, glycine, adenine, and guanine for the synthesis of nucleic acid purines have been… Expand