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Further study of the structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes.
TLDR
The structure of lentinan, an anti-tumor polysaccharide from Lentinus edodes, has been further investigated and it is shown that a branched molecule having a backbone of (1→3)-β-d-glucan and side chains of both β-d-(1→ 3)- and β- d-( 1→6)-linked d- glucose residues is present.
Antitumor activity and novel DNA‐self‐strand‐breaking mechanism of CNDAC (1‐(2‐C‐cyano‐2‐deoxy‐β‐d‐ARABINO‐Pentofuranosyl) cytosine) and its N4‐palmitoyl derivative (CS‐682)
TLDR
CNDAC is converted to CNDACMP by deoxycytidine kinase and that the resulting CNDacTP incorporated into a DNA strand as CND ACMP may induce DNA‐self‐strand‐breakage, which may contribute to the potent antitumor activity of CS‐682.
Design, synthesis, and antineoplastic activity of 2'-deoxy-2'-methylidenecytidine.
TLDR
L'activite anticancereux est etudiee in vitro le compose du titre a partir de l'uridine et du methylene trimethyl phosphorane.
Nucleosides and nucleotides. 185. Synthesis and biological activities of 4'alpha-C-branched-chain sugar pyrimidine nucleosides.
TLDR
Almost all of the nucleosides showed anti-HIV-1 activities, they were also cytotoxic to the host cells (MT-4) and antiviral activities against HSV-1,HSV-2, and HIV-1 in vitro were examined.
Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.).
TLDR
Three cardenolide glycosides obtained as the cytotoxic principles of "akond mul" showed similar cell line selectivity to those of cardiac glycoside such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 micrograms/ml.
Liposoluble platinum(II) complexes with antitumor activity.
TLDR
The former complexes had excellent antitumor activity without any toxicity to the host at the therapeutic dose when used with lipiodol as a carrier solvent and the latter complexes had neither antitUMor activity nor toxicity in vivo.
Comparison of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine with gemcitabine in its antitumor activity.
TLDR
4'-thio-FAC inhibited tumor growth more strongly than gemcitabine did at the same dose against human cancer cells implanted s.c. in nude mice, and suppressed the tumor growth by oral administration.
Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma
TLDR
It is suggested that hydrophobic drugs such as doxorubicin, being pumped out by P-glycoprotein, do not accumulate in 9L glioma cells as do other lipophilic drugs, such as ACNU, or drugssuch as 5-FU, which accumulate by a carrier-mediated mechanism.
Dependence on chain length of antitumor activity of (1 leads to 3)-beta-D-glucan from Alcaligenes faecalis var. myxogenes, IFO 13140, and its acid-degraded products.
TLDR
The results from the bioassay study of the low-molecular-weight (1 leads to 3)-beta-D-glucans prepared from the glucan with number-average degrees of polymerization (DPn) 540 by hydrolysis with formic acid or sulfuric acid showed that the glucans with DPn greater than 50 inhibited the growth of Sarcoma 180 implanted s.c. in mice.
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