Skip to search formSkip to main contentSkip to account menu

psorospermin

Known as: 6H-Furo(2,3-c)xanthen-6-one, 1,2-dihydro-10-hydroxy-5-methoxy-2-(2-methyloxiranyl)-, psorospermine 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Xanthones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Fused xanthone derivatives as antiproliferative agents.
Xanthones have been isolated from several natural sources, mainly belonging in Guttiferae and Gentianaceae families as secondary… 
2008
2008
Psorospermin structural requirements for P-glycoprotein resistance reversal
Resistance to chemotherapy reduces its effectiveness, resulting in increased mortality. Psorospermin, a natural product, is a… 
2005
2005
Conformationally restricted analogues of psorospermin: design, synthesis, and bioactivity of natural-product-related bisfuranoxanthones.
The antileukemic xanthone psorospermin is a topoisomerase II-dependent DNA alkylator in advanced preclinical development. Efforts… 
2005
2005
Determination of the importance of the stereochemistry of psorospermin in topoisomerase II–induced alkylation of DNA and in vitro and in vivo biological activity
Psorospermin is a natural product that has been shown to have activity against drug-resistant leukemia lines and AIDS-related… 
2003
2003
Design, synthesis, and evaluation of psorospermin/quinobenzoxazine hybrids as structurally novel antitumor agents.
Topoisomerase II, an enzyme that catalyzes changes in the topology of DNA, plays several key roles in DNA metabolism and… 
1999
1999
Structural Insight into a Quinolone-Topoisomerase II-DNA Complex
Quinobenzoxazine A-62176, developed from the antibacterial fluoroquinolones, is active in vitro andin vivo against murine and… 
1998
1998
Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites.
Psorospermin is a plant natural product that shows significant in vivo activity against P388 mouse leukemia. The molecular basis… 
1994
1994
Mechanism of action of the antileukemic xanthone psorospermin: DNA strand breaks, abasic sites, and protein-DNA cross-links.
Psorospermin, a cytotoxic dihydrofuranoxanthone isolated from Psorospermum febrifugum, produced aberrant simian virus 40 DNA… 
1993
1993
Gamma-pyrone compounds as potential anti-cancer drugs.
The gamma-pyrones, artomunoxanthotrione epoxide, cyclocommunol, cyclomulberrin, and cyclocommunin exhibited potent inhibition of… 
1986
1986
Antineoplastic agents from higher plants: application of tandem mass spectrometry to xanthones from Psorospermum febrifugum.
Psorospermum febrifugum was examined using tandem ms for the presence of 3',4'-deoxypsorospermin-4'-chloro-3'-ol and psorospermin… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)