pseudoproline

N-Glycosylation is an important posttranslational modification of proteins. A carbohydrate is transferred to an asparagine within… Expand

Peptidomimetic-based macrocycles typically have improved pharmacokinetic properties over those observed with peptide analogs… Expand

Post-translational modification of proteins with ubiquitin (Ub) and Ub chains controls protein breakdown by the proteasome… Expand

Cyclic tetrapeptides have generated great interest because of their broad-ranging biological properties. In order to synthesize… Expand

Traditionally, solid-phase synthesis has relied on polystyrene-based resins for the synthesis of all kinds of peptides. However… Expand

The efficient Fmoc solid-phase peptide synthesis of the 37-residue human Amylin and its amyloidogenic 8-37 fragment was achieved… Expand

Analogues of the opioid peptides [D-Phe(3)]morphiceptin (H-Tyr-Pro-D-Phe-Pro-NH(2)) and endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH(2… Expand

Molecular events such as cis/trans isomerization of Xaa-Pro tertiary amide bonds in peptides and proteins are slow on the overall… Expand

A comparative study has been undertaken between Hmb‐protected amino acid and pseudoproline building block analogues for use in… Expand

We describe the concept and the verification of a chemical ligation approach to the synthesis of proteins using peptide segments… Expand