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Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.
- E. Regalado, D. Taşdemir, M. Kaiser, N. Cachet, P. Amade, O. Thomas
- ChemistryJournal of Natural Products
- 8 July 2010
The chemical composition of the Caribbean sponge Pandaros acanthifolium was reinvestigated and led to the isolation of 12 new steroidal glycosides, namely, pandarosides E-J and their methyl esters (7-12), which showed in vitro activity against three or four parasitic protozoa.
Composition and Biological Properties of the Volatile Oil of Artemisia gorgonum Webb
- Risoleta Ortet, O. Thomas, E. Regalado, J. Pino, Jean-Jacques Filippi, M. Fernández
- Medicine, ChemistryChemistry and Biodiversity
- 1 May 2010
The volatile oil of this endemic plant was tested for its antioxidant and antimalarial properties, and was found to exhibit free‐radical scavenging on 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), prevention of lipid peroxidation–in vitro by TBARS (thiobarbituric acid reactive species) assay, and antiplasmodial activity.
Antitumor and Antimicrobial Potential of Bromoditerpenes Isolated from the Red Alga, Sphaerococcus coronopifolius
The aim of this study was to investigate the bioactivity of the main constituents of the cosmopolitan red alga, Sphaerococcus coronopifolius, to determine the structure of several bromoditerpenes which include a new brominated diterpene belonging to the rare dactylomelane family and named sphaerodactylmelol.
Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus
This work provides for the first time the chemical identification of the MTX3 molecule by NMR and biological data confirmed the similar activities of both gambierone and 44-methylgambierone.
Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum.
Metabolic fingerprinting as an indicator of biodiversity: towards understanding inter-specific relationships among Homoscleromorpha sponges
It is demonstrated that sponge chemical diversity may be useful for fundamental issues in systematics or evolutionary biology, by using metabolic fingerprints as indicators of metabolomic diversity in order to assess interspecific relationships.
Mahorones, highly brominated cyclopentenones from the red alga Asparagopsis taxiformis.
- S. Greff, M. Zubia, G. Genta‐Jouve, L. Massi, T. Pérez, O. Thomas
- BiologyJournal of Natural Products
- 18 April 2014
Phytochemical investigations performed on A. taxiformis gametophyte stages from the Indian Ocean revealed two new highly brominated cyclopentenones named mahorone and 5-bromomahorone, the first examples of natural 2,3-dibromocyclopenone derivatives.
Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B
This is the first report of an ASIC-current inhibitor derived of a marine-plant extract, and in a phenolic compound, and the active components of the extract are able to cross the blood-brain barrier.
Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells
Multidrug resistance has appeared to mitigate the efficiency of anticancer drugs and the possibility of successful cancer chemotherapy. The Hedgehog receptor Patched is a multidrug transporter…
How a collaborative integrated taxonomic effort has trained new spongiologists and improved knowledge of Martinique Island (French Antilles, eastern Caribbean Sea) marine biodiversity
The importance of developing exploratory and educational research in areas historically devoid of biodiversity inventories and systematics studies is demonstrated, as well as the necessity to consider not only the number of species but their distribution in space to evaluate their putative contribution to ecosystem services and willingness to preserve them.