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Antiprotozoal steroidal saponins from the marine sponge Pandaros acanthifolium.
The chemical composition of the Caribbean sponge Pandaros acanthifolium was reinvestigated and led to the isolation of 12 new steroidal glycosides, namely, pandarosides E-J and their methyl esters (7-12), which showed in vitro activity against three or four parasitic protozoa. Expand
Composition and Biological Properties of the Volatile Oil of Artemisia gorgonum Webb
The volatile oil of this endemic plant was tested for its antioxidant and antimalarial properties, and was found to exhibit free‐radical scavenging on 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH), prevention of lipid peroxidation–in vitro by TBARS (thiobarbituric acid reactive species) assay, and antiplasmodial activity. Expand
Sesquiterpene lactones from the endemic Cape Verdean Artemisia gorgonum.
Most compounds exhibited mild antiplasmodial activities, ridentin (13) being the most interesting with an IC(50) of 3.8+/-0.7microgml(-1) against Plasmodium falciparum FcB1 and weak cytotoxicity in a vero cell line. Expand
Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B
This is the first report of an ASIC-current inhibitor derived of a marine-plant extract, and in a phenolic compound, and the active components of the extract are able to cross the blood-brain barrier. Expand
Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells
Multidrug resistance has appeared to mitigate the efficiency of anticancer drugs and the possibility of successful cancer chemotherapy. The Hedgehog receptor Patched is a multidrug transporterExpand
How a collaborative integrated taxonomic effort has trained new spongiologists and improved knowledge of Martinique Island (French Antilles, eastern Caribbean Sea) marine biodiversity
The importance of developing exploratory and educational research in areas historically devoid of biodiversity inventories and systematics studies is demonstrated, as well as the necessity to consider not only the number of species but their distribution in space to evaluate their putative contribution to ecosystem services and willingness to preserve them. Expand
Metabolic fingerprinting as an indicator of biodiversity: towards understanding inter-specific relationships among Homoscleromorpha sponges
It is demonstrated that sponge chemical diversity may be useful for fundamental issues in systematics or evolutionary biology, by using metabolic fingerprints as indicators of metabolomic diversity in order to assess interspecific relationships. Expand
Allelopathic interactions between the brown algal genus Lobophora (Dictyotales, Phaeophyceae) and scleractinian corals
In situ observations in New Caledonia indicated that while allelopathic interactions are likely to occur at the macroalgal-coral interface, Lobophora spp. Expand
Mahorones, highly brominated cyclopentenones from the red alga Asparagopsis taxiformis.
Phytochemical investigations performed on A. taxiformis gametophyte stages from the Indian Ocean revealed two new highly brominated cyclopentenones named mahorone and 5-bromomahorone, the first examples of natural 2,3-dibromocyclopenone derivatives. Expand
Oscarella balibaloi, a new sponge species (Homoscleromorpha: Plakinidae) from the Western Mediterranean Sea: cytological description, reproductive cycle and ecology
It is shown that this homoscleromorph sponge species is becoming abundant in several locations and has a peculiar habit, often overgrowing massive sponges, gorgonians or some erected bryozoans. Expand