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protylonolide

Known as: Tylonolide, 20-deoxo-23-deoxy- 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

Tylosin
analogs & derivatives

Narrower (1)

tylactone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Feedback control of polyketide metabolism during tylosin production.
Tylosin is produced by Streptomyces fradiae via a combination of polyketide metabolism and synthesis of three deoxyhexose sugars… 
1986
1986
Mechanism of nitrogen regulation of protylonolide biosynthesis in Streptomyces fradiae.
A resting cell system was used to study the sites of inhibition by NH4+ of protylonolide biosynthesis by a blocked mutant, strain… 
Highly Cited
1984
Highly Cited
1984
Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone.
The production of tylosin by Streptomyces fradiae KA-427 in a defined medium was inhibited by ammonium ions and by inorganic… 
1984
1984
Ammonium ions suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae.
Protylonolide is a lactonic precursor of tylosin aglycone, produced by a mutant of Streptomyces fradiae. It originates from n… 
Highly Cited
1983
Highly Cited
1983
Valine as a precursor of n-butyrate unit in the biosynthesis of macrolide aglycone.
Sir: The biosynthesis of macrolide antibiotics is inhibited by ammonium ions.1) Previous papersl~3) from this laboratory reported… 
1983
1983
Chimeramycins: new macrolide antibiotics produced by hybrid biosynthesis.
Sir: Microbial conversion of antibiotically inactive macrocyclic lactones to active compounds is an important approach in the… 
1983
1983
Hybrid biosynthesis of a new macrolide antibiotic by a daunomycin-producing microorganism.
In previous papers1,2) we described the derivation of new macrolide antibiotics using the technique of hybrid biosynthesis. In a… 
1982
1982
Hybrid biosynthesis of derivatives of protylonolide and M-4365 by macrolide-producing microorganisms.
Biotransformation of a macrolide antibiotic and a related compound was studied using various macrolide-producing microorganisms… 
1982
1982
Novel fermentation products from Streptomyces fradiae: X-ray crystal structure of 5-O-mycarosyltylactone and proof of the absolute configuration of tylosin.
5-O-Mycarosyltylactone has been isolated as a predominant factor from fermentation broths of a Streptomyces fradiae mutant. The… 
1980
1980
X-ray crystallography of protylonolide and absolute configuration of tylosin.
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