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protein targeting to mitochondrion

Known as: protein import into mitochondrion, mitochondrial protein import, protein-mitochondrial targeting 
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained… Expand
National Institutes of Health

Related topics

Related topics

7 relations
mitochondrial translocationnegative regulation of protein targeting to mitochondrion

Broader (1)

mitochondrion organization

Narrower (4)

protein import into mitochondrial inner membraneprotein import into mitochondrial intermembrane spaceprotein import into mitochondrial matrixprotein import into mitochondrial outer membrane

Papers overview

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Highly Cited
2014
Highly Cited
2014
Inhibition of mitochondrial protein import by mutant huntingtin
Mitochondrial dysfunction is associated with neuronal loss in Huntington's disease (HD), a neurodegenerative disease caused by an… Expand
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Highly Cited
2012
Highly Cited
2012
Mitochondrial protein import: from transport pathways to an integrated network.
Mitochondria, the powerhouses of the cell, import most of their proteins from the cytosol. It was originally assumed that… Expand
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Highly Cited
2011
Highly Cited
2011
Regulation of Mitochondrial Protein Import by Cytosolic Kinases
Mitochondria import a large number of nuclear-encoded proteins via membrane-bound transport machineries; however, little is known… Expand
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Highly Cited
2009
Highly Cited
2009
Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import
Mitochondrial protein traffic requires coordinated operation of protein translocator complexes in the mitochondrial membrane. The… Expand
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Highly Cited
2007
Highly Cited
2007
Tim17p Regulates the Twin Pore Structure and Voltage Gating of the Mitochondrial Protein Import Complex TIM23*
The TIM23 complex mediates import of preproteins into mitochondria, but little is known of the mechanistic properties of this… Expand
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Highly Cited
2005
Highly Cited
2005
Ordered Assembly of Mitochondria During Rice Germination Begins with Promitochondrial Structures Rich in Components of the Protein Import Apparatus
Mitochondrial maturation during imbibition of rice embryos follows the transition of unstructured double membrane bound… Expand
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Highly Cited
2004
Highly Cited
2004
Pam16 has an essential role in the mitochondrial protein import motor
Mitochondrial preproteins destined for the matrix are translocated by two channel-forming transport machineries, the translocase… Expand
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Highly Cited
2002
Highly Cited
2002
Rapid regulation of steroidogenesis by mitochondrial protein import
Most mitochondrial proteins are synthesized on cytoplasmic ribosomes and imported into mitochondria. The imported proteins are… Expand
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Review
2001
Review
2001
Versatility of the mitochondrial protein import machinery
The vast majority of mitochondrial proteins are synthesized in the cytosol and are imported into mitochondria by protein… Expand
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Highly Cited
1991
Highly Cited
1991
Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences.
The transport of precursor proteins into mitochondria requires an energized inner membrane. We report here that the import of… Expand
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