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protein targeting to mitochondrion

Known as: protein import into mitochondrion, mitochondrial protein import, protein-mitochondrial targeting 
The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained… 
National Institutes of Health

Related topics

Related topics

7 relations
mitochondrial translocationnegative regulation of protein targeting to mitochondrion

Broader (1)

mitochondrion organization

Narrower (4)

protein import into mitochondrial inner membraneprotein import into mitochondrial intermembrane spaceprotein import into mitochondrial matrixprotein import into mitochondrial outer membrane

Papers overview

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Highly Cited
2013
Highly Cited
2013
A role for sequestosome 1/p62 in mitochondrial dynamics, import and genome integrity.
2012
2012
Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries
Abstract Mitochondrial protein import (MPI) is essential for the biogenesis of mitochondria in all eukaryotes. Current models of… 
Review
2008
Review
2008
Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10.
A number of molecular chaperones in mammalian cells are localized in mitochondria and they are presumed to function mainly within… 
2003
2003
Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway.
Thyroid hormone [3,5,3'-triiodo-l-thyronine (T(3))] induces phenotypic alterations in cardiac mitochondria, in part by… 
1999
1999
Characterization of the novel mitochondrial protein import component, Tom34, in mammalian cells.
Tom34 is a newly-found component of the mitochondrial protein import machinery in mammalian cells with no apparent counterpart in… 
Highly Cited
1997
Highly Cited
1997
Visualization of Mitochondrial Protein Import in Cultured Mammalian Cells with Green Fluorescent Protein and Effects of Overexpression of the Human Import Receptor Tom20*
The presequence of the ornithine transcarbamylase precursor (pOTC) was fused to green fluorescent protein (GFP), yielding pOTC… 
Highly Cited
1996
Highly Cited
1996
The mitochondrial protein import motor: Dissociation of mitochondrial hsp70 from its membrane anchor requires ATP binding rather than ATP hydrolysis
During protein import into mitochondria, matrix‐localized mitochondrial hsp70 (mhsp70) interacts with the inner membrane protein… 
Highly Cited
1995
Highly Cited
1995
A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex
Highly Cited
1993
Highly Cited
1993
Mas6p can be cross-linked to an arrested precursor and interacts with other proteins during mitochondrial protein import.
Mas6p is an integral membrane protein of the yeast mitochondrial inner membrane, which is essential for mitochondrial protein… 
Highly Cited
1988
Highly Cited
1988
Role of ATP in mitochondrial protein import. Conformational alteration of a precursor protein can substitute for ATP requirement.
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