protein TDP-43

Known as: TAR DNA-Binding Protein 43, TDP-43 
TAR DNA-binding protein 43 (414 aa, ~45 kDa) is encoded by the human TARDBP gene. This protein is involved in the regulation of both transcription… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
05010019952018

Papers overview

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Review
2016
Review
2016
Frontotemporal dementia is a devastating neurodegenerative disease causing stark alterations in personality and language… (More)
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Review
2016
Review
2016
Amyotrophic Lateral Sclerosis (ALS) is the most frequent motor neuron disease in adults. Classical ALS is characterized by the… (More)
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Highly Cited
2011
Highly Cited
2011
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as… (More)
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Highly Cited
2008
Highly Cited
2008
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND TDP-43 is a major component of the ubiquitinated inclusions that characterise amyotrophic lateral sclerosis (ALS) and… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE This study aimed to determine the frequency of frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-U… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Amyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. Approximately… (More)
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Highly Cited
2006
Highly Cited
2006
Ubiquitin-positive, tau- and alpha-synuclein-negative inclusions are hallmarks of frontotemporal lobar degeneration with… (More)
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Highly Cited
2006
Highly Cited
2006
Ubiquitin-positive tau-negative neuronal cytoplasmic inclusions and dystrophic neurites are common pathological features in… (More)
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Highly Cited
2006
Highly Cited
2006
We have investigated the extent and pattern of immunostaining for the TAR DNA-binding protein, TDP-43, in 37 patients with… (More)
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