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protein TDP-43

Known as: TAR DNA-Binding Protein 43, TDP-43 
TAR DNA-binding protein 43 (414 aa, ~45 kDa) is encoded by the human TARDBP gene. This protein is involved in the regulation of both transcription… 
National Institutes of Health

Related topics

Related topics

5 relations
Genes, RegulatorRNA SplicingTARDBP geneTARDBP wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Corrigendum: Structural Insights Into TDP-43 and Effects of Post-translational Modifications
[This corrects the article DOI: 10.3389/fnmol.2019.00301.]. 
2019
2019
Could Lifetime Lead Exposure Play a Role in Limbic-predominant Age-related TDP-43 Encephalopathy (LATE)?
Limbic-predominant Age-related TDP-43 Encephalopathy (LATE) is a disease whose clinical presentation mimics that of Alzheimer's… 
2017
2017
Imbalanced expression of polycistronic miRNA in acute myeloid leukemia
AbstractmiR-1 and miR-133 are clustered on the same chromosomal loci and are transcribed together as a single transcript that is… 
2016
2016
Supplemental Information ALS Mutations Disrupt Phase Separation Mediated by a-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
2014
2014
Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration
Pathological changes in corticobasal degeneration (CBD) consist of abnormal deposition of the microtubule-associated protein tau… 
Highly Cited
2012
Highly Cited
2012
TDP-1/TDP-43 Regulates Stress Signaling and Age-Dependent Proteotoxicity in Caenorhabditis elegans
TDP-43 is a multifunctional nucleic acid binding protein linked to several neurodegenerative diseases including Amyotrophic… 
2012
2012
Full-length TDP-43 and its C-terminal fragments activate mitophagy in NSC34 cell line
Review
2011
Review
2011
Redox signaling directly regulates TDP-43 via cysteine oxidation and disulfide cross-linking
Review timeline: Submission date: 10 February 2011 Editorial Decision: 02 March 2011 Additional correspondence (author): 03 March… 
Highly Cited
2009
Highly Cited
2009
TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases
Review
2008
Review
2008
[Significance of the TDP-43 deposition in FTLD-U and ALS].
Tau-negative and ubiquitin-positive inclusions (UPI) are the pathological hallmarks of frontotemporal lobar degeneration (FTLD-U… 
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