FAQ

TARDBP wt Allele

Known as: TDP-43, ALS10, TDP43 
Human TARDBP wild-type allele is located in the vicinity of 1p36.22 and is approximately 13 kb in length. This allele, which encodes TAR DNA-binding… (More)

Topic mentions per year

Topic mentions per year

2001-2018
02040608020012018

Related topics

Related topics

4 relations
RNA SplicingTranscriptional Regulationprotein TDP-43

Broader (1)

TARDBP gene

Related mentions per year

Related mentions per year

1968-2018
1960198020002020
TARDBP wt Allele
Transcriptional Regulation
RNA Splicing
protein TDP-43
TARDBP gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Prion-like propagation as a pathogenic principle in frontotemporal dementia.
Frontotemporal dementia is a devastating neurodegenerative disease causing stark alterations in personality and language… (More)
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Highly Cited
2011
Highly Cited
2011
Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as… (More)
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Highly Cited
2010
Highly Cited
2010
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo.
TDP-43 has been found in inclusion bodies of multiple neurological disorders, including amyotrophic lateral sclerosis… (More)
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Highly Cited
2008
Highly Cited
2008
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder characterized pathologically by ubiquitinated TAR DNA… (More)
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Highly Cited
2008
Highly Cited
2008
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Recently, TDP-43 was identified as a key component of ubiquitinated aggregates in amyotrophic lateral sclerosis (ALS), an adult… (More)
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Highly Cited
2008
Highly Cited
2008
TDP-43 A315T mutation in familial motor neuron disease.
To identify novel causes of familial neurodegenerative diseases, we extended our previous studies of TAR DNA-binding protein 43… (More)
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Highly Cited
2008
Highly Cited
2008
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis.
BACKGROUND TDP-43 is a major component of the ubiquitinated inclusions that characterise amyotrophic lateral sclerosis (ALS) and… (More)
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Highly Cited
2007
Highly Cited
2007
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations.
OBJECTIVE Amyotrophic lateral sclerosis (ALS) is a common, fatal motor neuron disorder with no effective treatment. Approximately… (More)
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Highly Cited
2006
Highly Cited
2006
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Ubiquitin-positive, tau- and alpha-synuclein-negative inclusions are hallmarks of frontotemporal lobar degeneration with… (More)
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Highly Cited
2006
Highly Cited
2006
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
Ubiquitin-positive tau-negative neuronal cytoplasmic inclusions and dystrophic neurites are common pathological features in… (More)
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