FAQ

prostaglandin-F synthase activity

Known as: NADPH-dependent prostaglandin D2 11-keto reductase activity, PGF2alpha synthetase activity, prostaglandin F synthase activity 
Catalysis of the reaction: NADP+ + (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate = NADPH + H+ + (5Z,13E)-(15S)-9-alpha,15… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2013
01219812013

Related topics

Related topics

1 relation

Broader (1)

prostaglandin metabolic process

Related mentions per year

Related mentions per year

1974-2018
197019801990200020102020
prostaglandin-F synthase activity
prostaglandin metabolic process

Papers overview

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2013
2013
Evaluation of the prostaglandin F synthase activity of human and bovine aldo-keto reductases: AKR1A1s complement AKR1B1s as potent PGF synthases.
AKR1B1 of the polyol pathway was identified as a prostaglandin F2α synthase (PGFS). Using a genomic approach we have identified… (More)
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2009
2009
AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.
Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of… (More)
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2006
2006
Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.
Prostaglandin H(2) (PGH(2)) formed from arachidonic acid is an unstable intermediate and is efficiently converted into more… (More)
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1998
1998
Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity.
Human 3alpha-hydroxysteroid dehydrogenase exists in four isoforms, which belong to the aldo-keto reductase (AKR) superfamily and… (More)
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1996
1996
Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.
We previously isolated three monomeric dihydrodiol dehydrogenases, DD1, DD2 and DD4, from human liver, and cloned a cDNA (C9… (More)
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1996
1996
A new reliable chemiluminescence immunoassay (CLIA) for prostaglandin E2 using enhanced luminol as substrate.
A sensitive and reliable chemiluminescence immunoassay suitable for the quantitative determination of prostaglandin E2 (PGE2) has… (More)
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1994
1994
Reduction of prostaglandin D2 to 9 alpha,11 beta-prostaglandin F2 by a human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozyme.
Prostaglandin (PG) specificity of two 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isozymes, DD2 and DD4, of human liver was… (More)
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1991
1991
Inhibition of rat brain prostaglandin D synthase by inorganic selenocompounds.
Various inorganic selenocompounds dose-dependently inhibited the rat brain prostaglandin (PG) D synthase, both in the purified… (More)
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1982
1982
Purification of PGD2 11-ketoreductase from rabbit liver.
 
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1981
1981
A novel prostaglandin 11-keto reductase found in rabbit liver.
The prostaglandin 11-keto reductase of rabbits, which catalyzes the conversion of prostaglandin D2 to prostaglandin F2 alpha, is… (More)
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