• Publications
  • Influence
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes.
A mAb J43 has been produced against the product of the mouse PD-1 gene, a member of the Ig gene superfamily, which was previously isolated from an apoptosis-induced T cell hybridoma (2B4.11) by usingExpand
  • 1,145
  • 42
  • PDF
Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu's arteritis.
Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of vascular cell injury in Takayasu's arteritis. To clarify the immunological mechanisms involved, we examined theExpand
  • 210
  • 5
  • PDF
Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity.
TNF-related apoptosis-inducing ligand (TRAIL) has been identified as a member of the TNF family that induces apoptosis in a variety of tumor cells, but its physiological functions are largelyExpand
  • 258
  • 4
  • PDF
Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes.
PD-1, a member of the Ig superfamily, was previously isolated from an apoptosis-induced T cell hybridoma 2B4.11 by subtractive hybridization. Expresson of the PD-1 mRNA is restricted to thymus inExpand
  • 204
  • 4
Müller cell protection of rat retinal ganglion cells from glutamate and nitric oxide neurotoxicity.
PURPOSE Low concentrations of excitotoxic agents such as glutamate and nitric oxide decrease survival rates of purified retinal ganglion cells (RGCs). In the retina, RGCs are ensheathed by retinalExpand
  • 119
  • 3
Antihypercholesterolemic activity of beta-sitostanol in rabbits.
The antihypercholesterolemic activity of beta-sitosterol and beta-sitostanol was compared in male rabbits given a cholesterol-supplemented diet. beta-Sitosterol and beta-sitostanol were fed to theseExpand
  • 44
  • 3
In vitro and in vivo effects of new powerful thromboxane antagonists (3-alkylamino pinane derivatives).
  • 57
  • 2
Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.
To investigate the mechanisms of T-cell-mediated cytotoxicity, we estimated the involvement of apoptosis-inducing Fas molecule on the target cells and its ligand on the effector cells. WhenExpand
  • 301
  • 2
Role of perforin in lymphocyte-mediated cytolysis.
Publisher Summary This chapter discusses structure and expression of perforin. Perforin is a primary candidate as mediator of the cellular cytotoxicity exhibited by cytotoxic T lymphocytes (CTLs) andExpand
  • 86
  • 2
Expression of perforin and cytolytic potential of human peripheral blood lymphocyte subpopulations.
To verify the physiological role of the pore-forming protein perforin in vivo, its expression in subpopulations of human peripheral blood lymphocytes was examined by immunocytochemical staining andExpand
  • 65
  • 2