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prostaglandin-E2 9-reductase activity

Known as: PGE2-9-ketoreductase activity, 9-keto-prostaglandin E2 reductase activity, reductase, 15-hydroxy-9-oxoprostaglandin 
Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Selective inhibition of methoxyflavonoids on human CYP1B1 activity.
Cytochrome P450 (CYP) 1B1 catalyzes 17beta-estradiol (E(2)) to predominantly carcinogenic 4-hydroxy-E(2), whereas CYP1A1 and 1A2… Expand
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2010
2010
Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects.
BACKGROUND Perennial allergic rhinitis (AR) is a common health problem with a high prevalence rate of 43.6% in Taiwan. In our… Expand
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2010
2010
Effect of IL‐1β, PGE2, and TGF‐β1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts
The RANKL/RANK/OPG pathway is essential for bone remodeling regulation. Many hormones and cytokines are involved in regulating… Expand
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1999
1999
Characterization of the lysyl adducts formed from prostaglandin H2 via the levuglandin pathway.
Prostaglandin H(2) has been demonstrated to rearrange to gamma-ketoaldehyde prostanoids termed levuglandins E(2) and D(2). As… Expand
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1997
1997
Identification of novel metabolites of prostaglandin E2 formed by isolated rat hepatocytes.
The metabolism of prostaglandin E2 (PGE2) in isolated rat hepatocytes led to the formation of four major as well as several minor… Expand
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Highly Cited
1996
Highly Cited
1996
Pharmacological studies on prostanoid receptors in the rabbit isolated saphenous vein: a comparison with the rabbit isolated ear artery
1 In isolated ring preparations of the rabbit saphenous vein, prostaglandin E2 (PGE2) caused well‐defined, stable and… Expand
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Highly Cited
1991
Highly Cited
1991
Subtype 2 Angiotensin Receptors Mediate Prostaglandin Synthesis in Human Astrocytes
We have identified two distinct cellular responses that occur in human astrocytes in the presence of angiotensin (Ang) peptides… Expand
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1988
1988
Involvement of prostaglandin E2, cAMP, and vasopressin in lithium-induced polyuria.
The involvement of prostaglandin E2 (PGE2), adenosine 3',5'-cyclic monophosphate (cAMP), and vasopressin in lithium-induced… Expand
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1982
1982
EFFECTS OF PROSTAGLANDINS AND THROMBOXANE ANALOGUES ON BULLOCK AND DOG IRIS SPHINCTER PREPARATIONS
1 The bullock iris sphincter was contracted by low concentrations of prostaglandin E2 (PGE2), 16,16‐dimethyl PGE2 and 17,18,19,20… Expand
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Highly Cited
1980
Highly Cited
1980
Accumulation of Cyclooxygenase Products of Arachidonic Acid Metabolism in Gerbil Brain During Reperfusion After Bilateral Common Carotid Artery Occlusion
: Several of the cyclooxygenase products of arachidonic acid were measured in the cerebral hemispheres of gerbils subjected to… Expand
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