prostaglandin-E2 9-reductase activity

Known as: PGE2-9-ketoreductase activity, 9-keto-prostaglandin E2 reductase activity, reductase, 15-hydroxy-9-oxoprostaglandin 
Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9… (More)
National Institutes of Health

Papers overview

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2010
2010
Effect of IL-1beta, PGE(2), and TGF-beta1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts.
The RANKL/RANK/OPG pathway is essential for bone remodeling regulation. Many hormones and cytokines are involved in regulating… (More)
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2010
2010
Selective inhibition of methoxyflavonoids on human CYP1B1 activity.
Cytochrome P450 (CYP) 1B1 catalyzes 17beta-estradiol (E(2)) to predominantly carcinogenic 4-hydroxy-E(2), whereas CYP1A1 and 1A2… (More)
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2010
2010
Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects.
BACKGROUND Perennial allergic rhinitis (AR) is a common health problem with a high prevalence rate of 43.6% in Taiwan. In our… (More)
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2009
2009
Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin.
Enhanced expression of cyclooxygenase-2 (COX-2) is associated with development of several cancers. The product of COX-2… (More)
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2008
2008
Anandamide inhibits IL-12p40 production by acting on the promoter repressor element GA-12: possible involvement of the COX-2 metabolite prostamide E(2).
The eCB [endoCB (cannabinoid)] system is being considered as a novel therapeutic target for immune disorders. Cytokines of the IL… (More)
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2000
2000
Pharmacological characterization of [(3)H]-prostaglandin E(2) binding to the cloned human EP(4) prostanoid receptor.
Prostaglandin (PG) E(2) (PGE(2)) is a potent prostanoid derived from arachidonic which can interact with EP(1), EP(2), EP(3) and… (More)
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2000
2000
Effects of some isoprostanes on the human umbilical artery in vitro.
1. Cumulative concentration-effect curves for the selective prostanoid TP receptor agonist U46619 and six isoprostanes were… (More)
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1991
1991
Subtype 2 angiotensin receptors mediate prostaglandin synthesis in human astrocytes.
We have identified two distinct cellular responses that occur in human astrocytes in the presence of angiotensin (Ang) peptides… (More)
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1988
1988
Involvement of prostaglandin E2, cAMP, and vasopressin in lithium-induced polyuria.
The involvement of prostaglandin E2 (PGE2), adenosine 3',5'-cyclic monophosphate (cAMP), and vasopressin in lithium-induced… (More)
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Highly Cited
1980
Highly Cited
1980
Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion.
Several of the cyclooxygenase products of arachidonic acid were measured in the cerebral hemispheres of gerbils subjected to… (More)
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