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Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework
Biomarker measurements provide an avenue for researchers to gain a mechanistic understanding of the differences in clinical response that may be influenced by uncontrolled variables (for example, drug metabolism). Expand
Lime and Limestone: Chemistry and Technology, Production and Uses
  • J. Oates
  • Chemistry, Materials Science
  • 8 July 1998
PRODUCTION OF LIMESTONE. Formation, Classification and Occurrence of Limestone. Physical and Chemical Properties of Limestone. Prospecting and Quarrying. Processing and Dispatch of Limestone.Expand
Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage.
The increased levels of F2-isoprostanes in the circulation of persons who smoke support the hypothesis that smoking can cause the oxidative modification of important biologic molecules in vivo. Expand
Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H2 synthases
The hypothesis that the clinical action of acetaminophen is mediated by inhibition of PGHS activity, and that hydroperoxide concentration contributes to its cellular selectivity, is supported. Expand
(R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2.
Substrate-selective inhibition provides new tools for investigating the role of COX-2 in endocannabinoid oxygenation and a possible explanation for the ability of (R)-profens to maintain endoc cannabinoidoid tone in models of neuropathic pain. Expand
Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen*
The results indicate that each of the pendant groups of the naphthyl scaffold are essential for COX inhibition, and only minimal substitutions are tolerated. Expand
New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases
Acetaminophen differs from the majority of nonsteroidal nti-inflammatory drugs (NSAIDs) and selective inhibtors of prostaglandin H2 synthase (PGHS) 2 because it acks significant antiinflammatory activity. Expand
Quantification of the major urinary metabolite of PGE2 by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE2 synthesis in healthy humans and those with
This work reports the development of a robust and facile method to measure urinary PGE-M excretion in humans using stable isotope dilution techniques employing liquid chromatography/tandem mass spectrometry (LC/MS/MS). Expand
Tristetraprolin Binds to the 3′-Untranslated Region of Cyclooxygenase-2 mRNA
Tristetraprolin, an mRNA-binding protein that promotes message instability, was shown to bind the cyclooxygenase-2 mRNA in the region of the 3′-untranslated region between nucleotides 3125 and 3432 and to reduce levels of the full-length mRNA. Expand
Cyclooxygenase-2 Promotes Early Atherosclerotic Lesion Formation in LDL Receptor–Deficient Mice
The present studies provide strong pharmacological and genetic evidence that COX-2 promotes early atherosclerotic lesion formation in LDLR−/− mice in vivo and support the potential of anti-inflammatory approaches to the prevention of atherosclerosis. Expand