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prophalan

National Institutes of Health

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Broader (2)

MelphalanProline
analogs & derivatives

Papers overview

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2007
2007
Proline Prodrug of Melphalan Targeted to Prolidase, a Prodrug Activating Enzyme Overexpressed in Melanoma
PurposeTo determine the bioactivation and uptake of prolidase-targeted proline prodrugs of melphalan in six cancer cell lines… 
2007
2007
Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model.
2005
2005
Prolidase, a potential enzyme target for melanoma: design of proline-containing dipeptide-like prodrugs.
Bioinformatics tools such as Perl, Visual Basic, Cluster, and TreeView were used to analyze public gene expression databases in… 
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