propentofylline

Known as: 1-(5'-oxohexyl)-3-methyl-7-propylxanthine, 3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl- 
 
National Institutes of Health

Papers overview

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2012
2012
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain cancer, with a median survival of less than 2 years… (More)
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Highly Cited
2008
Highly Cited
2008
In this study, we evaluated whether propentofylline, a methylxanthine derivative, modulates spinal glial activation and GABAergic… (More)
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2008
2008
We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve… (More)
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2006
2006
The development of painful peripheral neuropathy is a dose-limiting side effect of numerous cancer chemotherapeutic agents. The… (More)
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Highly Cited
2004
Highly Cited
2004
The activation of glial cells and enhanced proinflammatory cytokine expression at the spinal cord has been implicated in the… (More)
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Highly Cited
2003
Highly Cited
2003
Injury to peripheral nerves often produces non-physiological, long-lasting spontaneous pain, hyperalgesia and allodynia that are… (More)
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Highly Cited
2001
Highly Cited
2001
The present study was undertaken to determine whether propentofylline, a glial modulating agent, could both prevent the induction… (More)
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Review
1999
Review
1999
In addition to their well known roles within cells, purine nucleotides such as adenosine 5' triphosphate (ATP) and guanosine 5… (More)
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Review
1997
Review
1997
The mode of action of propentofylline (a xanthine derivative) suggested that it would have beneficial effects in patients with… (More)
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1988
1988
We studied the xanthine derivative propentofylline (HWA 285) to determine its protection against ischemic brain damage when… (More)
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