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propentofylline

Known as: 1-(5'-oxohexyl)-3-methyl-7-propylxanthine, 3,7-Dihydro-3-methyl-1-(5-oxohexyl)-7-propyl-1H-purine-2,6-dione, 1H-Purine-2,6-dione, 3,7-dihydro-3-methyl-1-(5-oxohexyl)-7-propyl- 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Accumulating evidence suggests that spinal cord astrocytes play an important role in neuropathic pain sensitization by releasing… Expand
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Highly Cited
2008
Highly Cited
2008
&NA; In this study, we evaluated whether propentofylline, a methylxanthine derivative, modulates spinal glial activation and… Expand
Review
2007
Review
2007
Guanine-based purines have been traditionally studied as modulators of intracellular processes, mainly G-protein activity… Expand
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Highly Cited
2004
Highly Cited
2004
The activation of glial cells and enhanced proinflammatory cytokine expression at the spinal cord has been implicated in the… Expand
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Review
2003
Review
2003
In many clinical pain syndromes, painful sensations are greatly amplified so that normally innocuous sensations, such as light… Expand
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Highly Cited
2003
Highly Cited
2003
Injury to peripheral nerves often produces non‐physiological, long‐lasting spontaneous pain, hyperalgesia and allodynia that are… Expand
Highly Cited
2001
Highly Cited
2001
The present study was undertaken to determine whether propentofylline, a glial modulating agent, could both prevent the induction… Expand
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Review
1999
Review
1999
In addition to their well known roles within cells, purine nucleotides such as adenosine 5' triphosphate (ATP) and guanosine 5… Expand
Highly Cited
1990
Highly Cited
1990
The role of adenosine in the development of ischemia induced pathological changes has been examined in Mongolian gerbils. A… Expand
Highly Cited
1990
Highly Cited
1990
1 The adenosine uptake blocker propentofylline (HWA 285) has previously been shown to protect hippocampal CA1 pyramidal cells… Expand