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prohormone

Known as: prohormones 
National Institutes of Health

Papers overview

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2007
2007
Neuropeptide precursors in Tribolium castaneum
Highly Cited
2000
Highly Cited
2000
Involvement of the membrane lipid bilayer in sorting prohormone convertase 2 into the regulated secretory pathway.
Prohormone convertase 2 (PC2) is a neuroendocrine-specific protease involved in the intracellular maturation of prohormones and… 
Highly Cited
1993
Highly Cited
1993
Gene expression of prohormone and proprotein convertases in the rat CNS: a comparative in situ hybridization analysis
Posttranslational processing of proproteins and prohormones is an essential step in the formation of bioactive peptides, which is… 
Review
1993
Review
1993
Mammalian Paired Basic Amino Acid Convertases of Prohormones and Proproteins a
The hypothesis of the existence of an inactive prohormone precursor was formulated in the mid-1960s. Over the years, the concept… 
Highly Cited
1992
Highly Cited
1992
Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
In recent studies we have identified PC2 and PC3, members of a family of serine proteases that are related structurally to… 
Highly Cited
1991
Highly Cited
1991
Cloning and functional expression of a novel endoprotease involved in prohormone processing at dibasic sites.
We cloned and sequenced a cDNA from a library of mouse pituitary AtT-20 cells which are known to cleave an endogenous and various… 
1987
1987
Human renin is correctly processed and targeted to the regulated secretory pathway in mouse pituitary AtT-20 cells.
Highly Cited
1983
Highly Cited
1983
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.
Review
1983
Review
1983
Proteases and posttranslational processing of prohormones: a review.
Pioneering work on insulin and on lipotropin, published in 1967, led to the formulation of the hypothesis that biologically… 
Highly Cited
1982
Highly Cited
1982
Characterization of pro-opiocortin-converting activity in purified secretory granules from rat pituitary neurointermediate lobe.
Lysates of secretory granules from rat pituitary neurointermediate lobes were incubated with [3H]arginine- or [3H]phenylalanine… 
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