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pro-diazepam

Known as: 2-benzoyl-4-chloromethyl-N-lysyl-glycinanilide, 2-benzoyl-4-chloromethyl-N-lysylglycin anilide, Avizafone 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Dipeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.
Current organophosphorus nerve agent medical countermeasures do not directly address the nicotinic effects of poisoning. A series… Expand
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2010
2010
Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine‐avizafone in healthy volunteers
BACKGROUND AND PURPOSE Treatment of organophosphate poisoning with pralidoxime needs to be improved. Here we have studied the… Expand
2008
2008
High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of diazepam, atropine and pralidoxime in human plasma.
A high-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) procedure for the… Expand
Review
2006
Review
2006
Pyridinium oximes: rationale for their selection as causal antidotes against organophosphate poisonings and current solutions for auto-injectors.
During the last five decades, five pyridinium oximes were found to be worthy of use as antidotes against nerve agents in humans… Expand
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2006
2006
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.
The purpose of the present study was to examine the efficacy of a triple combination of drugs with adequate anticonvulsant… Expand
2006
2006
Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig.
The purpose of this study was to compare the efficacy of diazepam and the pro-diazepam avizafone in preventing the severity of… Expand
2000
2000
Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning.
The main purpose of this study was to investigate the chemical stability of a new antidote combination for the treatment of… Expand
2000
2000
Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics
Abstract. We performed an experiment to characterize the toxicity of soman in cynomolgus monkeys in which organophosphorus… Expand
Highly Cited
1999
Highly Cited
1999
Comparative evaluation of benzodiazepines for control of soman-induced seizures
Abstract This study evaluated the ability of six benzodiazepines to stop seizures produced by exposure to the nerve agent soman… Expand
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Highly Cited
1993
Highly Cited
1993
Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats.
The purpose of this investigation was to compare the efficacy of diazepam and a water soluble pro-diazepam drug, avizafone (lysyl… Expand
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