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pro-diazepam

Known as: 2-benzoyl-4-chloromethyl-N-lysyl-glycinanilide, 2-benzoyl-4-chloromethyl-N-lysylglycin anilide, Avizafone 
 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Dipeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.
Current organophosphorus nerve agent medical countermeasures do not directly address the nicotinic effects of poisoning. A series… Expand
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2014
2014
Rapid Delivery of Diazepam from Supersaturated Solutions Prepared Using Prodrug/Enzyme Mixtures: Toward Intranasal Treatment of Seizure Emergencies
Current treatments for seizure emergencies, such as status epilepticus, include intravenous or rectal administration of… Expand
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2009
2009
Bioavailability of diazepam after intramuscular injection of its water-soluble prodrug alone or with atropine-pralidoxime in healthy volunteers.
BACKGROUND AND PURPOSE The aim of this study was to assess the relative bioavailability of diazepam after administration of… Expand
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2008
2008
High-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) method for the simultaneous determination of diazepam, atropine and pralidoxime in human plasma.
A high-performance liquid chromatography coupled with electrospray tandem mass spectrometry (LC/MS/MS) procedure for the… Expand
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2006
2006
Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.
The purpose of the present study was to examine the efficacy of a triple combination of drugs with adequate anticonvulsant… Expand
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2006
2006
Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig.
The purpose of this study was to compare the efficacy of diazepam and the pro-diazepam avizafone in preventing the severity of… Expand
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2003
2003
Comparative efficacy of diazepam and avizafone against sarin-induced neuropathology and respiratory failure in guinea pigs: influence of atropine dose.
This investigation compared the efficacy of diazepam and the water-soluble prodiazepam-avizafone-in sarin poisoning therapy… Expand
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2000
2000
Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics
Abstract. We performed an experiment to characterize the toxicity of soman in cynomolgus monkeys in which organophosphorus… Expand
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Highly Cited
1999
Highly Cited
1999
Comparative evaluation of benzodiazepines for control of soman-induced seizures
Abstract This study evaluated the ability of six benzodiazepines to stop seizures produced by exposure to the nerve agent soman… Expand
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1993
1993
Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats.
The purpose of this investigation was to compare the efficacy of diazepam and a water soluble pro-diazepam drug, avizafone (lysyl… Expand
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