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pro-diazepam

Known as: 2-benzoyl-4-chloromethyl-N-lysyl-glycinanilide, 2-benzoyl-4-chloromethyl-N-lysylglycin anilide, Avizafone 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Dipeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Diazepam prodrug stabilizes human aminopeptidase B during lyophilization.
Human aminopeptidase B (APB) is a hydrolytic zinc metalloenzyme currently being investigated as a biocatalyst for intranasal… 
2016
2016
Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines.
2016
2016
Pharmaceutics, Drug Delivery and Pharmaceutical Technology Chirally Pure Prodrugs and Their Converting Enzymes Lead to High Supersaturation and Rapid Transcellular Permeation of Benzodiazepines
Water-soluble prodrugs can be rapidly converted by enzymes to hydrophobic drugs, whose aqueous thermodynamic solubilities are low… 
2014
2014
Platform-Technology Based on Prodrug / Enzyme Systems for Rapid Absorption of Hydrophobic Drugs : Toward Intranasal Treatment of Seizure Emergencies
SUMMARY Poor water solubility of novel drugs is a key challenge in drug discovery and development as it results in low drug… 
2010
2010
Prediction of soman-induced cerebral damage by distortion product otoacoustic emissions.
2009
2009
Modélisation appliquée à la pharmacocinétique de molécules médicamenteuses indiquées en prévention ou en traitement d'atteintes neurologiques chez l'homme
L'aspect experimental de la pharmacocinetique necessite le developpement de techniques analytiques dans les milieux biologiques… 
2006
2006
Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig.
2006
2006
LC-UV and LC-MS evaluation of stress degradation behaviour of avizafone.
2004
2004
MANAGEMENT OF CONVULSIONS IN NERVE AGENT ACUTE POISONING: A POLISH PERSPECTIVE
Symptoms of acute poisoning with nerve agents such as organophosphorus (OP) compounds include general convulsions that could lead… 
2000
2000
Compared efficacy of diazepam or avizafone to prevent soman-induced electroencephalographic disturbances and neuropathology in primates: relationship to plasmatic benzodiazepine pharmacokinetics
Abstract. We performed an experiment to characterize the toxicity of soman in cynomolgus monkeys in which organophosphorus… 
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