Skip to search formSkip to main contentSkip to account menu

prelamin A

Known as: lamin A precursor 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Lamin Type A

Narrower (1)

progerin protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Accumulation of prelamin A induces premature aging through mTOR overactivation
Hutchinson‐Gilford progeria syndrome (HGPS) arises when a truncated form of farnesylated prelamin A accumulates at the nuclear… 
2019
2019
Prelamin A overexpression promotes detrusor calcification/aging in urinary incontinence via prelamin A accumulation
Urinary incontinence (UI) is known as a distressing condition particularly among older adults, and negatively associated with… 
2015
2015
Age-Related Lipid Metabolic Signature in Human LMNA-Lipodystrophic Stem Cell-Derived Adipocytes.
CONTEXT Lamin A (LMNA)-linked lipodystrophies belong to a group of clinical disorders characterized by a redistribution of… 
2015
2015
167 The pathogenic implications of prelamin a accumulation in cardiomyocytes: a model of premature cardiac senescence?
Introduction Mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamins A and C, lead to a… 
2013
2013
Is isoprenylcysteine carboxyl methyltransferase the key to reverse ageing?
Hutchinson-Gilford progeria (HGPS) is a rare, genetic progeroid disorder that causes premature ageing, nuclear lamina shape… 
2012
2012
Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24
Protein farnesyltransferase (FTase) inhibitors, generally called “FTIs,” block the farnesylation of prelamin A, inhibiting the… 
2010
2010
Prelamin A processing and functional effects in restrictive dermopathy
Laminopathies are an heterogeneous group of human disorders caused by mutations in the lamin A/C gene or in genes coding for… 
2008
2008
Drugs affecting prelamin A processing: effects on heterochromatin organization.
2007
2007
Inhibition of Protein Farnesylation Arrests Adipogenesis and Affects PPARγ Expression and Activation in Differentiating Mesenchymal Stem Cells
Protein farnesylation is required for the activation of multiple proteins involved in cell differentiation and function. In white… 
2007
2007
The prelamin A pre-peptide induces cardiac and skeletal myoblast differentiation.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)