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Lamin Type A

Known as: Lamin Type A [Chemical/Ingredient], Type A Lamins, Lamin A C 
A subclass of developmentally regulated lamins having a neutral isoelectric point. They are found to disassociate from nuclear membranes during… 
National Institutes of Health

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14 relations
In BloodLMNA geneProcess of secretionagonists

Narrower (4)

Lmna protein, mouseMUSCULAR DYSTROPHY, CONGENITAL, LMNA-RELATED (disorder)lamin Cprelamin A

Broader (1)

Nuclear lamin

Papers overview

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Highly Cited
2008
Highly Cited
2008
Increased mechanosensitivity and nuclear stiffness in Hutchinson–Gilford progeria cells: effects of farnesyltransferase inhibitors
Hutchinson–Gilford progeria syndrome (HGPS), reportedly a model for normal aging, is a genetic disorder in children marked by… 
Highly Cited
2007
Highly Cited
2007
Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration.
Lamin A/C is a major constituent of the nuclear lamina, a thin filamentous protein layer that lies beneath the nuclear envelope… 
Highly Cited
2007
Highly Cited
2007
US3 of Herpes Simplex Virus Type 1 Encodes a Promiscuous Protein Kinase That Phosphorylates and Alters Localization of Lamin A/C in Infected Cells
ABSTRACT The herpes simplex virus type 1 (HSV-1) US3 gene encodes a serine/threonine kinase that, when inactivated, causes… 
Highly Cited
2007
Highly Cited
2007
Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence
Lipodystrophic syndromes associated with mutations in LMNA, encoding A-type lamins, and with HIV antiretroviral treatments share… 
Highly Cited
2004
Highly Cited
2004
Methamphetamine induces neuronal apoptosis via cross‐talks between endoplasmic reticulum and mitochondria‐dependent death cascades
Methamphetamine (METH) is an illicit drug that causes neurodegenerative effects in humans. In rodents, METH induces apoptosis of… 
Highly Cited
2002
Highly Cited
2002
PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.
Autosomal dominant familial partial lipodystrophy (FPLD) due to mutant LMNA encoding nuclear lamin A/C is characterized by… 
Highly Cited
2002
Highly Cited
2002
A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor-γ Gene in a Patient with Familial Partial Lipodystrophy
Familial partial lipodystrophies (FPL) are a heterogeneous group of genetic disorders characterized by marked loss of… 
Highly Cited
1993
Highly Cited
1993
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.
Highly Cited
1987
Highly Cited
1987
Disassembly of the nucleus in mitotic extracts: Membrane vesicularization, lamin disassembly, and chromosome condensation are independent processes
Highly Cited
1984
Highly Cited
1984
Organization and Modulation of Nuclear Lamina Structure
SUMMARY The nuclear lamina is a protein meshwork associated with the nucleoplasmic surface of the inner nuclear membrane, that is… 
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