Skip to search formSkip to main contentSkip to account menu

LMNA gene

Known as: LAMIN C, HGPS, PROGERIN 
This gene is involved in the architecture of nuclear membrane construction.
National Institutes of Health

Related topics

Related topics

8 relations
Lamin Type AMandibuloacral dysostosisPrelamin-A/CProgeria

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
A homozygous mutation of prelamin-A preventing its farnesylation and maturation leads to a severe lipodystrophic phenotype: new insights into the pathogenicity of nonfarnesylated prelamin-A.
CONTEXT Mutations in LMNA, encoding A-type lamins, lead to multiple laminopathies, including lipodystrophies, progeroid syndromes… 
2010
2010
Progeria, the nucleolus and farnesyltransferase inhibitors.
HGPS (Hutchinson-Gilford progeria syndrome) is a rare genetic disease affecting children causing them to age and die prematurely… 
2007
2007
Common Variation in the LMNA Gene (Encoding Lamin A/C) and Type 2 Diabetes
Mutations in the LMNA gene (encoding lamin A/C) underlie familial partial lipodystrophy, a syndrome of monogenic insulin… 
2006
2006
Plasmid DNA and siRNA transfection of intestinal epithelial monolayers by electroporation.
Highly Cited
2005
Highly Cited
2005
Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C.
2005
2005
Defective prelamin A processing resulting from LMNA or ZMPSTE24 mutations as the cause of restrictive dermopathy.
2002
2002
Molecular characterization of protein kinase C-alpha binding to lamin A.
Previous results from our laboratory have identified lamin A as a protein kinase C (PKC)-binding protein. Here, we have… 
2002
2002
An LMNA variant is associated with dyslipidemia and insulin resistance in the Japanese.
Nuclear lamins A and C are encoded by LMNA and are present in terminally differentiated cells. Rare mutations in LMNA were shown… 
2001
2001
The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin
Most pathogenic missense mutations in the lamin A/C gene identified so far cause autosomal-dominant dilated cardiomyopathy and/or… 
Highly Cited
1995
Highly Cited
1995
Xenopus lamin B3 has a direct role in the assembly of a replication competent nucleus: evidence from cell-free egg extracts.
Xenopus egg extracts which assemble replication competent nuclei in vitro were depleted of lamin B3 using monoclonal antibody L6… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)