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LMNA gene

Known as: LAMIN C, HGPS, PROGERIN 
This gene is involved in the architecture of nuclear membrane construction.
National Institutes of Health

Related topics

Related topics

8 relations
Lamin Type AMandibuloacral dysostosisPrelamin-A/CProgeria

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models
The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a… 
Highly Cited
2015
Highly Cited
2015
Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells
For the past several decades, research in understanding the molecular basis of human aging has progressed significantly with the… 
2011
2011
A homozygous mutation of prelamin-A preventing its farnesylation and maturation leads to a severe lipodystrophic phenotype: new insights into the pathogenicity of nonfarnesylated prelamin-A.
CONTEXT Mutations in LMNA, encoding A-type lamins, lead to multiple laminopathies, including lipodystrophies, progeroid syndromes… 
2009
2009
Comprehensive mutation scanning of LMNA in 268 patients with lone atrial fibrillation.
Highly Cited
2008
Highly Cited
2008
A Potent HIV Protease Inhibitor, Darunavir, Does Not Inhibit ZMPSTE24 or Lead to an Accumulation of Farnesyl-prelamin A in Cells*
HIV protease inhibitors (HIV-PIs) are key components of highly active antiretroviral therapy, but they have been associated with… 
Highly Cited
2005
Highly Cited
2005
Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C.
2001
2001
The R482Q lamin A/C mutation that causes lipodystrophy does not prevent nuclear targeting of lamin A in adipocytes or its interaction with emerin
Most pathogenic missense mutations in the lamin A/C gene identified so far cause autosomal-dominant dilated cardiomyopathy and/or… 
Highly Cited
2000
Highly Cited
2000
LMNA R482Q mutation in partial lipodystrophy associated with reduced plasma leptin concentration.
Mutations in LMNA, which encodes lamins A and C, have been found in patients with autosomal dominant Dunnigan-type familial… 
Highly Cited
1995
Highly Cited
1995
Xenopus lamin B3 has a direct role in the assembly of a replication competent nucleus: evidence from cell-free egg extracts.
Xenopus egg extracts which assemble replication competent nuclei in vitro were depleted of lamin B3 using monoclonal antibody L6… 
Highly Cited
1993
Highly Cited
1993
Use of a general purpose mammalian expression vector for studying intracellular protein targeting: identification of critical residues in the nuclear lamin A/C nuclear localization signal.
We have constructed a general purpose mammalian expression vector for the study of intracellular protein targeting. The vector… 
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