Renal clearance of quantum dots
- H. Choi, Wenhao Liu, J. Frangioni
- BiologyNature Biotechnology
- 1 October 2007
This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.
Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins.
- J. Frangioni, B. Neel
- BiologyAnalytical Biochemistry
- 1 April 1993
This work has adapted a protocol, previously used to solubilize actin, for the purification of otherwise insoluble GST fusion proteins, and demonstrates that saturation of glutathione agarose is dependent on fusion protein molecular weight.
Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping
- Sungjee Kim, Y. Lim, J. Frangioni
- Physics, BiologyNature Biotechnology
- 2004
It is demonstrated that the fluorescence emission of type II quantum dots can be tuned into the near infrared while preserving absorption cross-section, and that a polydentate phosphine coating renders them soluble, disperse and stable in serum.
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport
It is shown that the leucine-rich region within the COOH-terminal α-helix of 14-3-3, which had been proposed to function as a nuclear export signal (NES), instead functions globally in ligand binding and does not directly mediate nuclear transport.
Initiation of myoblast to brown fat switch by a PRDM 16 – C / EBP-b transcriptional complex
- S. Kajimura, P. Seale, B. Spiegelman
- Biology
- 2009
It is shown that PRDM16 forms a transcriptional complex with the active form of C/EBP-b (also known as LAP), acting as a critical molecular unit that controls the cell fate switch from myoblastic precursors to brown fat cells.
In vivo near-infrared fluorescence imaging.
- J. Frangioni
- Biology, ChemistryCurrent Opinion in Chemical Biology
- 1 October 2003
The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence
- J. Frangioni, P. Beahm, V. Shifrin, C. A. Jost, B. Neel
- BiologyCell
- 7 February 1992
Initiation of myoblast/brown fat switch through a PRDM16-C/EBP-β transcriptional complex
- S. Kajimura, P. Seale, B. Spiegelman
- BiologyNature
- 28 July 2009
It is shown that PRDM16 forms a transcriptional complex with the active form of C/EBP-β (also known as LAP), acting as a critical molecular unit that controls the cell fate switch from myoblastic precursors to brown fat cells.
New technologies for human cancer imaging.
- J. Frangioni
- MedicineJournal of Clinical Oncology
- 20 August 2008
The physics and chemistry of cancer imaging is analyzed and the fundamental principles underlying the detection of malignant cells within a background of normal cells are highlighted.
Rapid translocation of nanoparticles from the lung airspaces to the body
- H. Choi, Yoshitomo Ashitate, A. Tsuda
- BiologyNature Biotechnology
- 1 November 2010
It is demonstrated that nanoparticles with hydrodynamic diameter less than ≈34 nm and a noncationic surface charge translocate rapidly from the lung to mediastinal lymph nodes and the bloodstream, and then be subsequently cleared by the kidneys.
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