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Current insights into LMNA cardiomyopathies: Existing models and missing LINCs
ABSTRACT The nuclear lamina is a critical structural domain for the maintenance of genomic stability and whole-cell mechanics. Mutations in the LMNA gene, which encodes nuclear A-type lamins lead to… Expand
Rnd3 induces stress fibres in endothelial cells through RhoB
- Undine Gottesbühren, R. Garg, P. Riou, B. McColl, Daniel Brayson, A. Ridley
- Medicine, Biology
- Biology Open
- 10 December 2012
Summary Rnd proteins are atypical Rho family proteins that do not hydrolyse GTP and are instead regulated by expression levels and post-translational modifications. Rnd1 and Rnd3/RhoE induce loss of… Expand
Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies
Cardiomyopathies are complex heart muscle diseases that can be inherited or acquired. Dilated cardiomyopathy can result from mutations in LMNA, encoding the nuclear intermediate filament proteins… Expand
Muscle tensions merge to cause a DNA replication crisis
Brayson et al. preview work from Wong et al. that provides evidence supporting the hypothesis that cell and tissue mechanics play a crucial role in the regulation of key nuclear functions.
The Nuclear Envelope in Cardiac Health and Disease
The nuclear envelope (NE) is a double membrane bilayer, which serves to compartmentalise the nuclear environment from the cytoplasm and regulate the movement of molecules in and out of the nucleus.… Expand
The nuclear envelope: LINCing tissue mechanics to genome regulation in cardiac and skeletal muscle
Regulation of the genome is viewed through the prism of gene expression, DNA replication and DNA repair as controlled through transcription, chromatin compartmentalisation and recruitment of repair… Expand
Transcriptomic and histological analysis of right ventricular myocardium in patients with tetralogy of Fallot repair undergoing pulmonary valve replacement
167 The pathogenic implications of prelamin a accumulation in cardiomyocytes: a model of premature cardiac senescence?
Introduction Mutations in the LMNA gene, which encodes the nuclear intermediate filament proteins lamins A and C, lead to a number of premature ageing syndromes, including Hutchinson Gilford Progeria… Expand
Accumulation of prelamin A drives inflammation in the heart with implications for treatment of inherited and acquired cardiomyopathies
Cardiomyopathies are complex heart muscle diseases that can be inherited e.g. dilated cardiomyopathy resulting from LMNA gene mutations, or acquired, e.g. cardiomyopathy associated with HIV. In both… Expand