posaconazole

Known as: posaconazole [Chemical/Ingredient] 
A broad-spectrum, second generation, triazole compound with antifungal activity. Posaconazole strongly inhibits 14-alpha demethylase, a cytochrome… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
A four-part, randomized, crossover study with healthy subjects evaluated the effects of gastric pH, the dosing frequency and… (More)
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Highly Cited
2006
Highly Cited
2006
Zygomycosis, an infection that is associated with significant morbidity and mortality, is becoming common in immunocompromised… (More)
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Highly Cited
2006
Highly Cited
2006
To evaluate the activity of posaconazole for treatment of zygomycosis, a disease for which therapeutic options are limited, we… (More)
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Highly Cited
2006
Highly Cited
2006
The in vitro activity of the novel triazole antifungal agent posaconazole (Noxafil; SCH 56592) was assessed in 45 laboratories… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Conventional amphotericin B-based antifungal therapy for invasive fusariosis in patients with a hematologic malignancy… (More)
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Review
2005
Review
2005
Posaconazale is a new triazole drug being investigated in phase III clinical trials for the treatment and prevention of invasive… (More)
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Highly Cited
2003
Highly Cited
2003
AIMS This randomized, crossover, single-dose study evaluated the relative oral bioavailability of posaconazole suspension and… (More)
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Highly Cited
2003
Highly Cited
2003
We examined the in vitro activity of caspofungin, posaconazole, voriconazole, ravuconazole, itraconazole, and amphotericin B… (More)
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Highly Cited
2003
Highly Cited
2003
The pharmacokinetics, safety, and tolerability of posaconazole, an investigational triazole antifungal, were evaluated following… (More)
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