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polyketide biosynthetic process

Known as: polyketide anabolism, polyketide synthesis, polyketide formation 
The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly… 
National Institutes of Health

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2 relations
negative regulation of polyketide biosynthetic processpositive regulation of polyketide biosynthetic process

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
The biochemical basis for stereochemical control in polyketide biosynthesis.
One of the most striking features of complex polyketides is the presence of numerous methyl- and hydroxyl-bearing stereogenic… 
Highly Cited
2006
Highly Cited
2006
Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus pneumoniae*
β-Ketoacyl-ACP synthases catalyze the condensation steps in fatty acid and polyketide synthesis and are targets for the… 
2005
2005
The Lego-ization of polyketide biosynthesis
A modular method for assembling polyketide synthases accelerates the generation of new polyketides. 
Highly Cited
2004
Highly Cited
2004
Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli.
2004
2004
Stereochemically rich pentaketides from bis(isoxazolines): a general strategy for efficient polyketide synthesis.
[reaction: see text] A strategy based on diastereoselective dipolar cycloaddition reaction of nitrile oxides and allylic… 
Highly Cited
2002
Highly Cited
2002
A Novel Biosynthetic Pathway Providing Precursors for Fatty Acid Biosynthesis and Secondary Metabolite Formation in Myxobacteria*
Short chain carboxylic acids are well known as the precursors of fatty acid and polyketide biosynthesis. Iso-fatty acids, which… 
Review
2001
Review
2001
Type I polyketide biosynthesis in bacteria (part B).
  • B. Rawlings
  • Natural product reports (Print)
  • 2001
  • Corpus ID: 20404515
Review
2001
Review
2001
Engineering of complex polyketide biosynthesis — insights from sequencing of the monensin biosynthetic gene cluster
The biosynthesis of complex reduced polyketides is catalysed in actinomycetes by large multifunctional enzymes, the modular Type… 
1996
1996
Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.
6-Deoxyerythronolide B synthase (DEBS) is a modular polyketide synthase (PKS) that catalyzes the biosynthesis of the parent… 
Highly Cited
1992
Highly Cited
1992
6-Deoxyerythronolide-B synthase 2 from Saccharopolyspora erythraea. Cloning of the structural gene, sequence analysis and inferred domain structure of the multifunctional enzyme.
Sequencing of the eryA region of the erythromycin biosynthetic gene cluster from Saccharopolyspora erythraea has revealed another… 
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