polyketide biosynthetic process

Known as: polyketide anabolism, polyketide synthesis, polyketide formation 
The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly… (More)
National Institutes of Health

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negative regulation of polyketide biosynthetic processpositive regulation of polyketide biosynthetic process

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Highly Cited
2007
Highly Cited
2007
Synthesis of unnatural flavonoids and stilbenes by exploiting the plant biosynthetic pathway in Escherichia coli.
Flavonoids and stilbenes have attracted much attention as potential targets for nutraceuticals, cosmetics, and pharmaceuticals… (More)
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Highly Cited
2005
Highly Cited
2005
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
Type I polyketide synthase (PKS) genes consist of modules ∼3–6 kb long, which encode the structures of 2-carbon units in… (More)
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Review
2003
Review
2003
Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms.
  • Ben Shen
  • Current opinion in chemical biology
  • 2003
Recent literature on polyketide biosynthesis suggests that polyketide synthases have much greater diversity in both mechanism and… (More)
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Highly Cited
2003
Highly Cited
2003
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis.
Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains… (More)
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2001
2001
Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering.
Polyketides, a large family of bioactive natural products, are synthesized from building blocks derived from alpha-carboxylated… (More)
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Highly Cited
2000
Highly Cited
2000
Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.
Chalcone synthase (CHS) catalyzes formation of the phenylpropanoid chalcone from one p-coumaroyl-CoA and three malonyl-coenzyme A… (More)
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Highly Cited
1999
Highly Cited
1999
Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis
Chalcone synthase (CHS) is pivotal for the biosynthesis of flavonoid antimicrobial phytoalexins and anthocyanin pigments in… (More)
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Highly Cited
1999
Highly Cited
1999
A new pathway for polyketide synthesis in microorganisms
Chalcone synthases, which biosynthesize chalcones (the starting materials for many flavonoids,), have been believed to be… (More)
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Highly Cited
1992
Highly Cited
1992
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
DNA isolated from the wild-type aflatoxin-producing (Afl+) fungus Aspergillus parasiticus NRRL 5862 was used to construct a… (More)
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Highly Cited
1991
Highly Cited
1991
Modular organization of genes required for complex polyketide biosynthesis.
In Saccharopolyspora erythraea, the genes that govern synthesis of the polyketide portion of the macrolide antibiotic… (More)
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