polyglutamates

Known as: polyglutamate 
 
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
The existence of an ATP-dependent methotrexate (MTX) efflux mechanism has long been postulated; however, until recently, the… (More)
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Review
2003
Review
2003
The non-ionic surfactants Cremophor EL (CrEL; polyoxyethyleneglycerol triricinoleate 35) and polysorbate 80 (Tween) 80… (More)
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Highly Cited
2002
Highly Cited
2002
Human MRP4 (ABCC4, MOAT-B) is a lipophilic anion transporter that is able to confer resistance to nucleotide analogues and… (More)
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Highly Cited
1998
Highly Cited
1998
A common mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) (5-methyltetrahydrofolate… (More)
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Highly Cited
1997
Highly Cited
1997
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo… (More)
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Highly Cited
1996
Highly Cited
1996
Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is… (More)
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1991
1991
The interaction of the mono- and triglutamate forms of 5-methyltetrahydrofolate and 5-formyltetrahydrofolate with serine… (More)
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Highly Cited
1986
Highly Cited
1986
With the use of a continuous spectrophotometric assay and initial rates determined by the method of Waley [Biochem. J. (1981) 193… (More)
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Highly Cited
1986
Highly Cited
1986
Serum and red blood cell methotrexate (MTX) levels, as well as hepatic levels of MTX and folate, were analyzed in 24 patients who… (More)
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Highly Cited
1982
Highly Cited
1982
To determine the pharmacologic importance of methotrexate (MTX) polyglutamates, we examined the formation, retention, and effect… (More)
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