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polyglutamates

Known as: polyglutamate 
 
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
ABCG2 is a plasma membrane efflux pump that is able to confer resistance to several anticancer agents, including mitoxantrone… Expand
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Highly Cited
2003
Highly Cited
2003
The existence of an ATP-dependent methotrexate (MTX) efflux mechanism has long been postulated; however, until recently, the… Expand
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Highly Cited
2002
Highly Cited
2002
Human MRP4 (ABCC4, MOAT-B) is a lipophilic anion transporter that is able to confer resistance to nucleotide analogues and… Expand
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Highly Cited
1999
Highly Cited
1999
Transfection of multidrug resistance proteins (MRPs) MRP1 and MRP2 in human ovarian carcinoma 2008 cells conferred a marked level… Expand
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Highly Cited
1997
Highly Cited
1997
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo… Expand
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Highly Cited
1991
Highly Cited
1991
N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N- methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is a water… Expand
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Highly Cited
1986
Highly Cited
1986
Serum and red blood cell methotrexate (MTX) levels, as well as hepatic levels of MTX and folate, were analyzed in 24 patients who… Expand
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Highly Cited
1985
Highly Cited
1985
We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic… Expand
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Highly Cited
1985
Highly Cited
1985
We have studied the effects of methotrexate (MTX-Glu1) and the polyglutamate derivatives of methotrexate (MTXPGs) with 2, 3, 4… Expand
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Highly Cited
1982
Highly Cited
1982
To determine the pharmacologic importance of methotrexate (MTX) polyglutamates, we examined the formation, retention, and effect… Expand
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